Effects of Low-intensity Exercise on Cognitive Function, Blood Biomarkers, and Metabolomic Alterations of Older Adults at Risk of Developing Dementia

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study aims to examine the effects of low-intensity, combined physical-cognitive exercise on cognitive function of older people with mild cognitive impairment (MCI) and identify the mechanisms by which this exercise protocol exerts cognitive function. Older adults with MCI will be recruited to either an exercise or a control group. Low-intensity, combined physical-cognitive exercise will be prescribed to the exercise group 3 times per week for 3 months while the control group will maintain their routine lifestyle. It is hypothesized that at the end of the trial, participants in the exercise group will demonstrate significant improvement in cognitive performance and circulating biomarkers compared to baseline and the control group.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: f
View:

• meeting the criteria for MCI (or mNCD) based on the recent DSM-V criteria

• comprehend instructions and able to comply with the study procedures

• not taking any medications for their cognition and not planning to start medications during the study trial

Locations
Other Locations
Thailand
Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University
RECRUITING
Chiang Mai
Contact Information
Primary
S Kumfu
sirintip.ku@up.ac.th
6653949249
Time Frame
Start Date: 2024-04-07
Estimated Completion Date: 2026-10
Participants
Target number of participants: 64
Treatments
Experimental: Low-intensity, combined physical-cognitive exercise
The exercise program will be prescribed at low intensity for 50 minutes/session, 3 times /week for 12 consecutive weeks.
No_intervention: Control
Participants will be asked to maintain their routine lifestyle throughout the study period.
Related Therapeutic Areas
Sponsors
Leads: Chiang Mai University

This content was sourced from clinicaltrials.gov