Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Healthy Volunteers: f
View:

• 50 years of age and older

• Admitted to the intensive care for greater \> 48 hours

• Able to understand and provide informed consent

• Validated depression diagnosis (PHQ-9 \> 10)

• Willing to participate in cognitive testing

• Access to a telephone

• Discharge to home or an independent or assisted living facility

Locations
United States
Indiana
Eskenazi Hospital
RECRUITING
Indianapolis
IU Health Methodist Hospital
RECRUITING
Indianapolis
Contact Information
Primary
Babar Khan, MD, MS
bakhan@iu.edu
317-274-9132
Backup
Lori Rawlings, RN, BSN
rawlingl@regenstrief.org
317-274-9052
Time Frame
Start Date: 2025-03-13
Estimated Completion Date: 2029-10-30
Participants
Target number of participants: 300
Treatments
Experimental: Intervention - Internet Cognitive-Behavioral Therapy (CBT) for Depression
Participants will complete nine 45-minute sessions of an internet CBT for depression called Good Days Ahead (GDA; MindStreet, Inc.) with 20 minutes of therapist assistance per session on the phone over six months.
Active_comparator: Active Control - Depression Education, Symptom Monitoring, and Usual Care
Participants will review nine 45-minute segments of depression education material on their own with 20 minutes of therapist assistance per segment on the phone over six months. They will also have access to and could receive current depression care in the targeted healthcare systems.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute on Aging (NIA)
Leads: Indiana University

This content was sourced from clinicaltrials.gov