A Study of Remternetug Versus Placebo in Early Alzheimer's Disease Participants at Risk for Cognitive and Functional Decline
Status: Recruiting
Location: See all (272) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's disease occurring in participants receiving study drug compared to placebo. Participation could last up to 255 weeks including screening, a double-blind treatment period, and a double-blind observation period. In addition, eligible participants who receive placebo during the double-blind treatment period may choose to extend their study participation to receive open-label remternetug in an extension period.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Maximum Age: 80
Healthy Volunteers: f
View:
• Have a phosphorylated tau (P-tau) result consistent with the presence of amyloid pathology.
• Have a reliable study partner and backup study partner familiar with overall function and behavior, such as day-to-day activities and cognitive abilities.
• Have adequate literacy, vision, and hearing for neuropsychological testing at screening.
• Have a Mini Mental Status Exam (MMSE) score consistent with no to minimal cognitive impairment.
• Have a Functional Activities Questionnaire (FAQ) score consistent with no to minimal functional impairment.
• If currently receiving medications as symptomatic treatment for AD, dose has been stable for at least 30 days before screening.
Locations
United States
Alabama
Parkway Medical Center
RECRUITING
Birmingham
Arizona
MD First Research - Chandler
RECRUITING
Chandler
Care Access - 801 South Power Road, Mesa
RECRUITING
Mesa
Banner Alzheimer's Institute
RECRUITING
Phoenix
Banner Alzheimer's Institute Tucson
RECRUITING
Tucson
California
Neuro-Pain Medical Center
RECRUITING
Fresno
Care Access - Huntington Beach
RECRUITING
Huntington Beach
Inglewood Clinical
RECRUITING
Inglewood
Irvine Clinical Research
RECRUITING
Irvine
Healthy Brain Clinic
RECRUITING
Long Beach
Riverside Clinical
RECRUITING
Riverside
Clinical Trials Research
RECRUITING
Sacramento
Artemis Institute for Clinical Research
RECRUITING
San Diego
Sharp Neurocognitive Research Center
RECRUITING
San Diego
Ray Dolby Brain Health Center
RECRUITING
San Francisco
The Neuron Clinic - San Marcos
RECRUITING
San Marcos
Syrentis Clinical Research
RECRUITING
Santa Ana
Providence Medical Foundation
RECRUITING
Santa Rosa
California Neuroscience Research, LLC
RECRUITING
Sherman Oaks
Colorado
Care Access - Aurora
RECRUITING
Aurora
Mountain Neurological Research Center
RECRUITING
Basalt
Alpine Clinical Research Center
RECRUITING
Boulder
CenExel Rocky Mountain Clinical Research
RECRUITING
Englewood
Connecticut
Invicro
RECRUITING
New Haven
Ki Health Partners, LLc, dba New England Institute for Clinical Research
RECRUITING
Stamford
Florida
JEM Research Institute
RECRUITING
Atlantis
VIN - Aventura
RECRUITING
Aventura
Bradenton Research Center, Inc.
RECRUITING
Bradenton
K2 Medical Research WINTER GARDEN
RECRUITING
Clermont
TecTum Research
RECRUITING
Davie
Brain Matters Research
RECRUITING
Delray Beach
Neuropsychiatric Research Center of Southwest Florida
RECRUITING
Fort Myers
Indago Research & Health Center, Inc
RECRUITING
Hialeah
K2 MEDICAL Research THE VILLAGES
RECRUITING
Lady Lake
ClinCloud
RECRUITING
Maitland
K2 Medical Research ORLANDO
RECRUITING
Maitland
ClinCloud
RECRUITING
Melbourne
Merritt Island Medical Research, LLC
RECRUITING
Merritt Island
New Age Medical Research Corporation
RECRUITING
Miami
VIN-Andrew Lerman
RECRUITING
Miami
Adult Medicine of Lake County, Inc.
RECRUITING
Mt. Dora
Aqualane Clinical Research
RECRUITING
Naples
Suncoast Clinical Research, Inc.
RECRUITING
New Port Richey
Renstar Medical Research
RECRUITING
Ocala
AdventHealth Orlando
RECRUITING
Orlando
Charter Research - Winter Park
RECRUITING
Orlando
Emerald Coast Neurology - Airport Boulevard
RECRUITING
Pensacola
Progressive Medical Research
RECRUITING
Port Orange
Alzheimer's Research and Treatment Center
RECRUITING
Stuart
Axiom Brain Health LLC
RECRUITING
Tampa
Care Access - Tampa
RECRUITING
Tampa
Stedman Clinical Trials
RECRUITING
Tampa
Charter Research - Lady Lake
RECRUITING
The Villages
Alzheimer's Research and Treatment Center
RECRUITING
Wellington
Palm Beach Neurology
RECRUITING
West Palm Beach
Conquest Research
RECRUITING
Winter Park
Georgia
Columbus Memory Center, LLC
RECRUITING
Columbus
Care Access - Decatur
RECRUITING
Decatur
Center for Advanced Research & Education
RECRUITING
Gainesville
North Georgia Clinical Research
RECRUITING
Woodstock
Iowa
Cedar Valley Medical Specialists
RECRUITING
Waterloo
Idaho
Northwest Clinical Trials
RECRUITING
Boise
Illinois
Care Access - Arlington Heights
RECRUITING
Arlington Heights
Great Lakes Clinical Trials - Andersonville
RECRUITING
Chicago
Re:Cognition Health - Chicago
RECRUITING
Chicago
Alexian Brothers Medical Center
RECRUITING
Elk Grove Village
Indiana
Care Access - South Indianapolis
RECRUITING
Indianapolis
Josephson Wallack Munshower Neurology, PC
RECRUITING
Indianapolis
Kansas
Cotton O'Neil Clinical Research Center
RECRUITING
Topeka
Louisiana
Care Access - Lake Charles (Bayou Pines)
RECRUITING
Lake Charles
Tandem Clinical Research
RECRUITING
Marrero
Massachusetts
Adams Clinical Boston
RECRUITING
Boston
Boston Clinical Trials
RECRUITING
Boston
Boston Center for Memory
RECRUITING
Newton
Care Access - Quincy
RECRUITING
Quincy
MedVadis Research Corporation
RECRUITING
Waltham
Adams Clinical Watertown
RECRUITING
Watertown
Maryland
Care Access - Baltimore
RECRUITING
Baltimore
Maine
Acadia Hospital
RECRUITING
Bangor
Michigan
Revival Research Institute, LLC
RECRUITING
Dearborn
QUEST Research Institute
RECRUITING
Farmington Hills
Minnesota
HealthPartners Neuroscience Center
RECRUITING
Saint Paul
Missouri
Citizens Memorial Hospital District
RECRUITING
Bolivar
Clinical Research Professionals
RECRUITING
Chesterfield
Mississippi
Private Practice - Dr. Ronald Louis Schwartz
RECRUITING
Hattiesburg
North Carolina
Care Access - Charlotte
RECRUITING
Charlotte
Medication Management
RECRUITING
Greensboro
Monroe Biomedical Research
RECRUITING
Monroe
Nebraska
University Of Nebraska Medical Center
RECRUITING
Omaha
New Jersey
Care Access - Hoboken
RECRUITING
Hoboken
The Cognitive and Research Center of New Jersey - Ridgewood
RECRUITING
Ridgewood
The Cognitive and Research Center of New Jersey
RECRUITING
Springfield
Advanced Memory Research Institute of New Jersey
RECRUITING
Toms River
New Mexico
IMA Clinical Research
RECRUITING
Albuquerque
Nevada
Vector Clinical Trials
RECRUITING
Las Vegas
Ohio
Care Access - Lima
RECRUITING
Lima
North Star Medical Research
RECRUITING
Middleburg Heights
Oregon
Summit Headlands
RECRUITING
Portland
Pennsylvania
Clinical Research of Philadelphia
RECRUITING
Philadelphia
Keystone Clinical Studies
RECRUITING
Plymouth Meeting
Rhode Island
Rhode Island Mood & Memory Research Institute
RECRUITING
East Providence
Butler Hospital
RECRUITING
Providence
South Carolina
Tribe Clinical Research, LLC
RECRUITING
Greenville
Palmetto Clinical Research
RECRUITING
Summerville
Tennessee
Neurology Clinic, P.C.
RECRUITING
Cordova
Genesis Neuroscience Clinic
RECRUITING
Knoxville
Texas
Senior Adults Specialty Research
RECRUITING
Austin
Gadolin Research
RECRUITING
Beaumont
Kerwin Medical Center
RECRUITING
Dallas
Kerwin Medical Center - Oak Cliff
RECRUITING
Dallas
Care Access - Georgetown
RECRUITING
Georgetown
Care Access - Houston
RECRUITING
Houston
Next Level Urgent Care
RECRUITING
Houston
The University of Texas Health Science Center at Houston
RECRUITING
Houston
El Faro Health and Therapeutics
RECRUITING
Rio Grande City
Central Texas Neurology Consultants, PA
RECRUITING
Round Rock
IMA Clinical Research San Antonio
RECRUITING
San Antonio
Consano Clinical Research, LLC
RECRUITING
Shavano Park
Virginia
Care Access - Arlington 2
RECRUITING
Arlington
Re:Cognition Health
RECRUITING
Fairfax
Eastern Virginia Medical School (EVMS) Medical Group
RECRUITING
Norfolk
Washington
Northwest Clinical Research Center
RECRUITING
Bellevue
Rainier Clinical Research Center
RECRUITING
Renton
Other Locations
Argentina
Centro Médico Arsema
NOT_YET_RECRUITING
Buenos Aires
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI)
NOT_YET_RECRUITING
Buenos Aires
Instituto Argentino de Investigación Neurológica (IADIN)
NOT_YET_RECRUITING
Buenos Aires
Instituto Médico Especializado (IME)
NOT_YET_RECRUITING
Buenos Aires
IDIM - Instituto de Investigaciones Metabólicas
NOT_YET_RECRUITING
Ciudad De Buenos Aires
CEN Centro Especializado en Neurociencias
NOT_YET_RECRUITING
Córdoba
Instituto Kremer
NOT_YET_RECRUITING
Córdoba
Fundacion Estudios Clinicos
NOT_YET_RECRUITING
Rosario
Centro de Investigaciones Médicas Tucuman
NOT_YET_RECRUITING
San M. De Tucuman
Australia
USC Clinical Trials Sunshine Coast
RECRUITING
Birtinya
Emeritus Research
RECRUITING
Botany
Box Hill Hospital
RECRUITING
Box Hill
Emeritus Research
RECRUITING
Camberwell
GenesisCare - Maitland
RECRUITING
East Maitland
The University of Queensland
RECRUITING
Herston
Ipswich Hospital
RECRUITING
Ipswich
Austin Health
RECRUITING
Ivanhoe
Southern Neurology
RECRUITING
Kogarah
KARA Institute for Neurological Diseases
RECRUITING
Macquarie Park
HammondCare
RECRUITING
Malvern
Fusion Clinical Research
RECRUITING
Norwood
The Royal Melbourne Hospital
RECRUITING
Parkville
USC Clinical Trials Brisbane (South Bank)
RECRUITING
South Brisbane
St Vincent's Hospital
RECRUITING
Sydney
The Queen Elizabeth Hospital
RECRUITING
Woodville
Canada
Ecogene-21 - Cmas
RECRUITING
Chicoutimi
MoCA Research and Innovation Inc.
RECRUITING
Greenfield Park
OCT Research ULC
RECRUITING
Kelowna
Alpha Recherche Clinique - Lévis
RECRUITING
Lévis
Clinique Mémoire de Montréal
RECRUITING
Montreal
Genge Partners
RECRUITING
Montreal
Ottawa Memory Clinic
RECRUITING
Ottawa
Kawartha Centre - Redefining Healthy Aging
RECRUITING
Peterborough
Alpha Recherche Clinique
RECRUITING
Québec
ALPHA Recherche Clinique
RECRUITING
Québec
Bluewater Clinical Research Group Inc.
RECRUITING
Sarnia
Q&T Research Sherbrooke Inc.
RECRUITING
Sherbrooke
Baycrest Health Sciences
RECRUITING
Toronto
Sunnybrook Research Institute
RECRUITING
Toronto
Toronto Memory Program
RECRUITING
Toronto
Diex Recherche Victoriaville
RECRUITING
Victoriaville
The Medical Arts Health Research Group - West Vancouver
RECRUITING
West Vancouver
China
Beijing Anding Hospital - Affiliated Capital University of Medical Science
RECRUITING
Beijing
Beijing Tiantan Hospital Affiliated to Capital Medical University
RECRUITING
Beijing
The First Hospital of Jilin University
RECRUITING
Changchun
Xiangya Hospital Central South University
RECRUITING
Changsha
Sichuan Provincial People's Hospital
RECRUITING
Chengdu
Guangdong Provincial People's Hospital
RECRUITING
Guangzhou
Guangzhou First People's Hospital
RECRUITING
Guangzhou
Guangzhou Medical University 2nd Hospital
RECRUITING
Guangzhou
Zhujiang Hospital
RECRUITING
Guangzhou
Anhui Provincial Hospital
RECRUITING
Hefei
Jinan Central Hospital
RECRUITING
Jinan
The First Affiliated Hospital of Henan University of Science &Technology
RECRUITING
Luoyang
The First Affiliated Hospital of Nanchang University
RECRUITING
Nanchang
The Second Affiliated Hospital of Nanchang University
RECRUITING
Nanchang
Nanjing Brain Hospital
RECRUITING
Nanjing
Sir Run Run Hospital of Nanjing Medical University
RECRUITING
Nanjing
Huashan Hospital, Fudan University
RECRUITING
Shanghai
Pudong New Area People's Hospital Shanghai
RECRUITING
Shanghai
Renji Hospital Shanghai Jiao Tong University School of Medicine
RECRUITING
Shanghai
Shanghai Sixth People's Hospital
RECRUITING
Shanghai
The First Hospital of Hebei Medical University
RECRUITING
Shijiazhuang
The Second Affiliated Hospital of Soochow University
RECRUITING
Suzhou
Tianjin Medical University General Hospital
RECRUITING
Tianjin
Shaanxi provincial people's hospital
RECRUITING
Xi'an
The First Affiliated Hospital of Xi'an Medical University
RECRUITING
Xi'an
Xianyang Hospital of Yan'an University
RECRUITING
Xianyang
The Affiliated Hospital of Xuzhou Medical College
RECRUITING
Xuzhou
Xuzhou Central Hospital
RECRUITING
Xuzhou
Zigong First People's Hospital
RECRUITING
Zigong
Japan
The University of Tokyo Hospital
RECRUITING
Bunkyō City
Fukuwa Clinic
RECRUITING
Chūōku
Medical Corporation Chiseikai Tokyo Center Clinic
RECRUITING
Chūōku
Tokyo Asbo Clinic
RECRUITING
Chūōku
Tokyo-Eki Center-building Clinic
RECRUITING
Chūōku
Kawashima Neurology Clinic
RECRUITING
Fujisawa
Boocs Clinic Fukuoka
RECRUITING
Fukuoka
UNB Sumiyoshi Jinjamae Clinic
RECRUITING
Fukuoka
P-One Clinic
RECRUITING
Hachiōji
Hyogo Prefectural Harima-Himeji General Medical Center
RECRUITING
Himeji
Saiseikai Imabari Hospital
RECRUITING
Imabari
Kobe University Hospital
RECRUITING
Kobe
Showa General Hospital
RECRUITING
Kodaira
Tatsuoka Neurology Clinic
RECRUITING
Kyoto
Sakurazaka Clinic SophyAnce
RECRUITING
Minatoku
National Center for Geriatrics and Gerontology
RECRUITING
Ōbu
Iwata Neurosurgery Clinic
RECRUITING
Osaka
Kanto Central Hospital
RECRUITING
Setagaya-ku
Samoncho Clinic
RECRUITING
Shinjuku
Clinical Research Hospital Tokyo
RECRUITING
Shinjuku-ku
Heishinkai Medical Group ToCROM Clinic
RECRUITING
Shinjuku-ku
Higashi Shinjuku Clinic
RECRUITING
Shinjuku-ku
Medical Corporation Heishinkai OCROM Clinic
RECRUITING
Suita-shi
Tokyo Metropolitan Geriatric Hospital
RECRUITING
Tabashi City
Tachikawa Hospital
RECRUITING
Tachikawa
Takatsuki Hospital
RECRUITING
Takatsuki-shi
Wako Hospital
RECRUITING
Wako
Puerto Rico
SCB Research Center
RECRUITING
Bayamón
Caribbean Medical Research Center
RECRUITING
San Juan
INSPIRA Clinical Research
RECRUITING
San Juan
Instituto De Neurologia Dra. Ivonne Fraga
RECRUITING
San Juan
Republic of Korea
Pusan National University Hospital
RECRUITING
Busan
Chungbuk National University Hospital
RECRUITING
Cheongju-si
Gangnam Severance Hospital, Yonsei University Health System
RECRUITING
Gangnam-gu
Ewha Womans University Seoul Hospital
RECRUITING
Gangseo-gu
Chonnam National University Hospital
RECRUITING
Gwangju
Inha University Hospital
RECRUITING
Incheon
Jeju National University Hospital
RECRUITING
Jeju City
Gachon University Gil Medical Center
RECRUITING
Namdong-gu
Seoul National University Bundang Hospital
RECRUITING
Seongnam
Asan Medical Center
RECRUITING
Seoul
Hanyang University Seoul Hospital
RECRUITING
Seoul
Konkuk University Medical Center
RECRUITING
Seoul
Samsung Medical Center
RECRUITING
Seoul
Seoul National University Hospital
RECRUITING
Seoul
Seoul National University Hospital
RECRUITING
Seoul
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING
Seoul
Ajou University Hospital
RECRUITING
Suwon
Wonju Severance Christian Hospital
RECRUITING
Wŏnju
Spain
Barcelonabeta Brain Research Center
ACTIVE_NOT_RECRUITING
Barcelona
Fundació ACE
ACTIVE_NOT_RECRUITING
Barcelona
Hospital Clínic de Barcelona
ACTIVE_NOT_RECRUITING
Barcelona
Hospital de la Santa Creu i Sant Pau
ACTIVE_NOT_RECRUITING
Barcelona
Hospital Universitario Quironsalud Madrid
ACTIVE_NOT_RECRUITING
Pozuelo De Alarcón
Policlinica Gipuzkoa
ACTIVE_NOT_RECRUITING
San Sebastián
Hospital Victoria Eugenia
ACTIVE_NOT_RECRUITING
Seville
Taiwan
Changhua Christian Hospital
RECRUITING
Changhua County
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region
RECRUITING
Douliu
Chang Gung Memorial Hospital at Kaohsiung
RECRUITING
Kaohsiung Niao Sung Dist
New Taipei Municipal TuCheng Hospital
RECRUITING
New Taipei City
Taipei Medical University Shuang Ho Hospital
RECRUITING
New Taipei City
China Medical University Hospital
RECRUITING
Taichung
Taichung Veterans General Hospital
RECRUITING
Taichung
National Taiwan University Hospital
RECRUITING
Taipei
Taipei Veterans General Hospital
RECRUITING
Taipei
Chang Gung Medical Foundation-Linkou Branch
RECRUITING
Taoyuan District
United Kingdom
ReMind UK
RECRUITING
Bath
Re:Cognition Health - Birmingham
RECRUITING
Birmingham
Layton Medical Centre
RECRUITING
Blackpool
Scottish Brain Sciences
RECRUITING
Edinburgh
St Pancras Clinical Research
RECRUITING
London
NIHR Manchester Clinical Research Facility
RECRUITING
Manchester
NeuroClin
RECRUITING
Motherwell
Roborough Surgery
RECRUITING
Plymouth
Homecroft Surgery
RECRUITING
Redruth
Abbeywell Surgery
RECRUITING
Romsey
Moorgreen Hospital
RECRUITING
Southampton
Marine Lake Medical Practice
RECRUITING
West Kirby
Contact Information
Primary
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
LillyTrials@Lilly.com
1-317-615-4559
Backup
Physicians interested in becoming principal investigators please contact
clinical_inquiry_hub@lilly.com
Time Frame
Start Date: 2024-10-24
Estimated Completion Date: 2030-10
Participants
Target number of participants: 1400
Treatments
Experimental: Remternetug
Remternetug administered subcutaneously (SC).
Placebo_comparator: Placebo
Placebo administered SC.
Related Therapeutic Areas
Sponsors
Leads: Eli Lilly and Company