A Study of Remternetug Versus Placebo in Early Alzheimer's Disease Participants at Risk for Cognitive and Functional Decline
Status: Active_not_recruiting
Location: See all (262) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's disease occurring in participants receiving study drug compared to placebo. Participation could last up to 255 weeks including screening, a double-blind treatment period, and a double-blind observation period. In addition, eligible participants who receive placebo during the double-blind treatment period may choose to extend their study participation to receive open-label remternetug in an extension period.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Maximum Age: 80
Healthy Volunteers: f
View:
• Have a phosphorylated tau (P-tau) result consistent with the presence of amyloid pathology.
• Have a reliable study partner and backup study partner familiar with overall function and behavior, such as day-to-day activities and cognitive abilities.
• Have adequate literacy, vision, and hearing for neuropsychological testing at screening.
• Have a Mini Mental Status Exam (MMSE) score consistent with no to minimal cognitive impairment.
• Have a Functional Activities Questionnaire (FAQ) score consistent with no to minimal functional impairment.
• If currently receiving medications as symptomatic treatment for AD, dose has been stable for at least 30 days before screening.
Locations
United States
Alabama
Parkway Medical Center
Birmingham
Arizona
MD First Research - Chandler
Chandler
Care Access - 801 South Power Road, Mesa
Mesa
Banner Alzheimer's Institute
Phoenix
Banner Alzheimer's Institute Tucson
Tucson
California
Neuro-Pain Medical Center
Fresno
Care Access - Huntington Beach
Huntington Beach
Inglewood Clinical
Inglewood
Irvine Clinical Research
Irvine
Healthy Brain Clinic
Long Beach
Riverside Clinical
Riverside
Clinical Trials Research
Sacramento
Artemis Institute for Clinical Research
San Diego
Sharp Neurocognitive Research Center
San Diego
Ray Dolby Brain Health Center
San Francisco
The Neuron Clinic - San Marcos
San Marcos
Syrentis Clinical Research
Santa Ana
Providence Medical Foundation
Santa Rosa
California Neuroscience Research, LLC
Sherman Oaks
Colorado
Care Access - Aurora
Aurora
Mountain Neurological Research Center
Basalt
Alpine Clinical Research Center
Boulder
CenExel Rocky Mountain Clinical Research
Englewood
Connecticut
Invicro
New Haven
Ki Health Partners, LLc, dba New England Institute for Clinical Research
Stamford
Florida
JEM Research Institute
Atlantis
VIN - Aventura
Aventura
Bradenton Research Center, Inc.
Bradenton
K2 Medical Research WINTER GARDEN
Clermont
TecTum Research
Davie
Brain Matters Research
Delray Beach
Neuropsychiatric Research Center of Southwest Florida
Fort Myers
Indago Research & Health Center, Inc
Hialeah
K2 MEDICAL Research THE VILLAGES
Lady Lake
ClinCloud
Maitland
K2 Medical Research ORLANDO
Maitland
ClinCloud
Melbourne
Merritt Island Medical Research, LLC
Merritt Island
New Age Medical Research Corporation
Miami
VIN-Andrew Lerman
Miami
Adult Medicine of Lake County, Inc.
Mt. Dora
Aqualane Clinical Research
Naples
Suncoast Clinical Research, Inc.
New Port Richey
Renstar Medical Research
Ocala
AdventHealth Orlando
Orlando
Charter Research - Winter Park
Orlando
Emerald Coast Neurology - Airport Boulevard
Pensacola
Progressive Medical Research
Port Orange
Alzheimer's Research and Treatment Center
Stuart
Axiom Brain Health LLC
Tampa
Care Access - Tampa
Tampa
Stedman Clinical Trials
Tampa
Charter Research - Lady Lake
The Villages
Alzheimer's Research and Treatment Center
Wellington
Palm Beach Neurology
West Palm Beach
Conquest Research
Winter Park
Georgia
Columbus Memory Center, LLC
Columbus
Care Access - Decatur
Decatur
Center for Advanced Research & Education
Gainesville
North Georgia Clinical Research
Woodstock
Iowa
Cedar Valley Medical Specialists
Waterloo
Idaho
Northwest Clinical Trials
Boise
Illinois
Care Access - Arlington Heights
Arlington Heights
Great Lakes Clinical Trials - Andersonville
Chicago
Re:Cognition Health - Chicago
Chicago
Alexian Brothers Medical Center
Elk Grove Village
Indiana
Care Access - South Indianapolis
Indianapolis
Josephson Wallack Munshower Neurology, PC
Indianapolis
Kansas
Cotton O'Neil Clinical Research Center
Topeka
Louisiana
Care Access - Lake Charles (Bayou Pines)
Lake Charles
Tandem Clinical Research
Marrero
Massachusetts
Adams Clinical Boston
Boston
Boston Clinical Trials
Boston
Boston Center for Memory
Newton
Care Access - Quincy
Quincy
MedVadis Research Corporation
Waltham
Adams Clinical Watertown
Watertown
Maryland
Care Access - Baltimore
Baltimore
Maine
Acadia Hospital
Bangor
Michigan
Revival Research Institute, LLC
Dearborn
QUEST Research Institute
Farmington Hills
Minnesota
HealthPartners Neuroscience Center
Saint Paul
Missouri
Citizens Memorial Hospital District
Bolivar
Clinical Research Professionals
Chesterfield
Mississippi
Private Practice - Dr. Ronald Louis Schwartz
Hattiesburg
North Carolina
Care Access - Charlotte
Charlotte
Medication Management
Greensboro
Monroe Biomedical Research
Monroe
Nebraska
University Of Nebraska Medical Center
Omaha
New Jersey
Care Access - Hoboken
Hoboken
The Cognitive and Research Center of New Jersey - Ridgewood
Ridgewood
The Cognitive and Research Center of New Jersey
Springfield
Advanced Memory Research Institute of New Jersey
Toms River
New Mexico
IMA Clinical Research
Albuquerque
Nevada
Vector Clinical Trials
Las Vegas
Ohio
Care Access - Lima
Lima
North Star Medical Research
Middleburg Heights
Oregon
Summit Headlands
Portland
Pennsylvania
Clinical Research of Philadelphia
Philadelphia
Keystone Clinical Studies
Plymouth Meeting
Rhode Island
Rhode Island Mood & Memory Research Institute
East Providence
Butler Hospital
Providence
South Carolina
Tribe Clinical Research, LLC- Greenville
Greenville
Palmetto Clinical Research
Summerville
Tennessee
Neurology Clinic, P.C.
Cordova
Genesis Neuroscience Clinic
Knoxville
Texas
Senior Adults Specialty Research
Austin
Gadolin Research
Beaumont
Kerwin Medical Center
Dallas
Kerwin Medical Center - Oak Cliff
Dallas
Care Access - Georgetown
Georgetown
Care Access - Houston
Houston
Next Level Urgent Care
Houston
The University of Texas Health Science Center at Houston
Houston
El Faro Health and Therapeutics
Rio Grande City
Central Texas Neurology Consultants, PA
Round Rock
IMA Clinical Research San Antonio
San Antonio
Consano Clinical Research, LLC
Shavano Park
Virginia
Care Access - Arlington 2
Arlington
Re:Cognition Health
Fairfax
Eastern Virginia Medical School (EVMS) Medical Group
Norfolk
Washington
Northwest Clinical Research Center
Bellevue
Rainier Clinical Research Center
Renton
Other Locations
Australia
USC Clinical Trials Sunshine Coast
Birtinya
Emeritus Research
Botany
Box Hill Hospital
Box Hill
Emeritus Research
Camberwell
GenesisCare - Maitland
East Maitland
The University of Queensland
Herston
Ipswich Hospital
Ipswich
Austin Health
Ivanhoe
Southern Neurology
Kogarah
KARA Institute for Neurological Diseases
Macquarie Park
HammondCare
Malvern
Fusion Clinical Research
Norwood
The Royal Melbourne Hospital
Parkville
USC Clinical Trials Brisbane (South Bank)
South Brisbane
St Vincent's Hospital
Sydney
The Queen Elizabeth Hospital
Woodville
Canada
Ecogene-21 - Cmas
Chicoutimi
MoCA Research and Innovation Inc.
Greenfield Park
OCT Research ULC
Kelowna
Alpha Recherche Clinique - Lévis
Lévis
Clinique Mémoire de Montréal
Montreal
Genge Partners
Montreal
Ottawa Memory Clinic
Ottawa
Kawartha Centre - Redefining Healthy Aging
Peterborough
Alpha Recherche Clinique
Québec
ALPHA Recherche Clinique
Québec
Bluewater Clinical Research Group Inc.
Sarnia
Q&T Research Sherbrooke Inc.
Sherbrooke
Baycrest Health Sciences
Toronto
Sunnybrook Research Institute
Toronto
Toronto Memory Program
Toronto
Diex Recherche Inc. Division Victoriaville
Victoriaville
The Medical Arts Health Research Group - West Vancouver
West Vancouver
China
Beijing Anding Hospital - Affiliated Capital University of Medical Science
Beijing
Beijing Tiantan Hospital Affiliated to Capital Medical University
Beijing
The First Hospital of Jilin University
Changchun
Xiangya Hospital Central South University
Changsha
Sichuan Provincial People's Hospital
Chengdu
Guangdong Provincial People's Hospital
Guangzhou
Guangzhou First People's Hospital
Guangzhou
Guangzhou Medical University 2nd Hospital
Guangzhou
Zhujiang Hospital
Guangzhou
Anhui Provincial Hospital
Hefei
Jinan Central Hospital
Jinan
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang
The First Affiliated Hospital of Nanchang University
Nanchang
The Second Affiliated Hospital of Nanchang University
Nanchang
Nanjing Brain Hospital
Nanjing
Sir Run Run Hospital of Nanjing Medical University
Nanjing
Huashan Hospital, Fudan University
Shanghai
Pudong New Area People's Hospital Shanghai
Shanghai
Renji Hospital Shanghai Jiao Tong University School of Medicine
Shanghai
Shanghai Sixth People's Hospital
Shanghai
The First Hospital of Hebei Medical University
Shijiazhuang
The Second Affiliated Hospital of Soochow University
Suzhou
Tianjin Medical University General Hospital
Tianjin
Shaanxi provincial people's hospital
Xi'an
The First Affiliated Hospital of Xi'an Medical University
Xi'an
Xianyang Hospital of Yan'an University
Xianyang
The Affiliated Hospital of Xuzhou Medical College
Xuzhou
Xuzhou Central Hospital
Xuzhou
Zigong First People's Hospital
Zigong
Japan
The University of Tokyo Hospital
Bunkyō City
Fukuwa Clinic
Chūōku
Medical Corporation Chiseikai Tokyo Center Clinic
Chūōku
Tokyo Asbo Clinic
Chūōku
Tokyo-Eki Center-building Clinic
Chūōku
Kawashima Neurology Clinic
Fujisawa
Boocs Clinic Fukuoka
Fukuoka
UNB Sumiyoshi Jinjamae Clinic
Fukuoka
P-One Clinic
Hachiōji
Hyogo Prefectural Harima-Himeji General Medical Center
Himeji
Saiseikai Imabari Hospital
Imabari
Kobe University Hospital
Kobe
Showa General Hospital
Kodaira
Tatsuoka Neurology Clinic
Kyoto
Sakurazaka Clinic SophyAnce
Minatoku
National Center for Geriatrics and Gerontology
Ōbu
Iwata Neurosurgery Clinic
Osaka
Kanto Central Hospital
Setagaya-ku
Samoncho Clinic
Shinjuku
Clinical Research Hospital Tokyo
Shinjuku-ku
Heishinkai Medical Group ToCROM Clinic
Shinjuku-ku
Higashi Shinjuku Clinic
Shinjuku-ku
Medical Corporation Heishinkai OCROM Clinic
Suita-shi
Tokyo Metropolitan Geriatric Hospital
Tabashi City
Tachikawa Hospital
Tachikawa
Takatsuki Hospital
Takatsuki-shi
Wako Hospital
Wako
Puerto Rico
SCB Research Center
Bayamón
Caribbean Medical Research Center
San Juan
INSPIRA Clinical Research
San Juan
Instituto De Neurologia Dra. Ivonne Fraga
San Juan
Republic of Korea
Pusan National University Hospital
Busan
Chungbuk National University Hospital
Cheongju-si
Gangnam Severance Hospital, Yonsei University Health System
Gangnam-gu
Ewha Womans University Seoul Hospital
Gangseo-gu
Chonnam National University Hospital
Gwangju
Inha University Hospital
Incheon
Jeju National University Hospital
Jeju City
Gachon University Gil Medical Center
Namdong-gu
Seoul National University Bundang Hospital
Seongnam
Asan Medical Center
Seoul
Hanyang University Seoul Hospital
Seoul
Konkuk University Medical Center
Seoul
Samsung Medical Center
Seoul
Seoul National University Hospital
Seoul
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul
Ajou University Hospital
Suwon
Wonju Severance Christian Hospital
Wŏnju
Spain
Barcelonabeta Brain Research Center
Barcelona
Fundació ACE
Barcelona
Hospital Clínic de Barcelona
Barcelona
Hospital de la Santa Creu i Sant Pau
Barcelona
Hospital Universitario Quironsalud Madrid
Pozuelo De Alarcón
Policlinica Gipuzkoa
San Sebastián
Hospital Victoria Eugenia
Seville
Taiwan
Changhua Christian Hospital
Changhua County
National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region
Douliu
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist
New Taipei Municipal TuCheng Hospital
New Taipei City
Taipei Medical University Shuang Ho Hospital
New Taipei City
China Medical University Hospital
Taichung
Taichung Veterans General Hospital
Taichung
National Taiwan University Hospital
Taipei
Taipei Veterans General Hospital
Taipei
Chang Gung Medical Foundation-Linkou Branch
Taoyuan District
United Kingdom
ReMind UK
Bath
Re:Cognition Health - Birmingham
Birmingham
Layton Medical Centre
Blackpool
Scottish Brain Sciences
Edinburgh
St Pancras Clinical Research
London
NIHR Manchester Clinical Research Facility
Manchester
NeuroClin
Motherwell
Roborough Surgery
Plymouth
Homecroft Surgery
Redruth
Abbeywell Surgery
Romsey
Moorgreen Hospital
Southampton
Marine Lake Medical Practice
West Kirby
Time Frame
Start Date: 2024-10-24
Completion Date: 2030-10
Participants
Target number of participants: 1400
Treatments
Experimental: Remternetug
Remternetug administered subcutaneously (SC).
Placebo_comparator: Placebo
Placebo administered SC.
Related Therapeutic Areas
Sponsors
Leads: Eli Lilly and Company