Prevalence and Care Partner Burden of Individuals With Alzheimer's Disease

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throughout the disease course in people with AD. The overall objective of this study is to evaluate swallowing function in adults with and without Alzheimer's disease. The investigator will also be involving the primary caregivers of individuals with Alzheimer's that are enrolled in the study to better understand the impact of swallowing impairments on the primary caregivers of those with Alzheimer's Disease. Healthy adults and individuals with Alzheimer's disease will: * undergo tests of cough and swallow function * undergo tests of grip and tongue strength * complete questionnaires Caregivers of individuals with Alzheimer's disease will also complete questionnaires.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: t
View:

• adult ≥60 years old

• diagnosis of AD by a neurologist (confirmed with imaging, spinal tap, behavioral testing)

• no prior history of other neurological diseases (aside from stroke which has resolved with no current symptoms)

• no prior history of respiratory diseases

• no prior history of head and neck surgery/head and neck cancer/radiation to head and neck region

• consuming some form of oral intake

• able to follow basic directions

• able/willing to provide consent/assent.

• care partner of an individual with AD

• willing to complete questionnaires/participate in an interview.

• adult ≥60 years old

• no prior history of neurological diseases (aside from stroke which has resolved with no current symptoms)

• no prior history of respiratory diseases

⁃ 3\) no prior history of head and neck surgery/head and neck cancer/radiation to head and neck region 4) no prior history of swallowing difficulties based on participant report. 5) Score ≥25th percentile based on sex/age/education/race on the Montreal Cognitive Assessment (MOCA)

Locations
United States
Tennessee
Vanderbilt University Medical Center
RECRUITING
Nashville
Contact Information
Primary
Cara Donohue, PhD CCC-SLP
cara.donohue@vumc.org
615-852-5085
Time Frame
Start Date: 2025-04-21
Estimated Completion Date: 2028-02
Participants
Target number of participants: 240
Treatments
Healthy community dwelling adults
Healthy adults ≥ 60 years old with no prior history of neurological or respiratory diseases, swallowing impairments, or history of head and neck surgery, cancer, or radiation to the head or neck will be enrolled in this study.
Adults with Alzheimer's Disease and their caregivers
Adults with a diagnosis of Alzheimer's disease and their caregivers will be enrolled in this study.
Related Therapeutic Areas
Sponsors
Leads: Vanderbilt University Medical Center

This content was sourced from clinicaltrials.gov