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Comparison of the Effects of Treadmill-Based Walking and Dual-Task Walking Training on Activity and Cognition in Alzheimer's Disease

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Alzheimer's disease is a neurodegenerative condition that affects both cognitive and motor functions, making daily life activities more challenging. Motor functions, especially walking and balance, begin to deteriorate early in the disease and progress in parallel with cognitive decline. Dual-task performance, which refers to the ability to perform both motor and cognitive tasks simultaneously, significantly decreases in individuals with Alzheimer's disease. Current studies suggest that dual-task exercises can improve both cognitive and motor functions. In this context, treadmill-based dual-task training emerges as a promising approach to mitigate the effects of Alzheimer's disease. The study hypothesizes that treadmill-based dual-task training will have more positive effects on motor and cognitive parameters compared to treadmill exercise alone in individuals with Alzheimer's disease. The main research question of this study is whether treadmill-based dual-task exercise training, designed with progressively more challenging cognitive and motor tasks and tailored to the individual, results in significant improvements in motor and cognitive parameters, as well as daily living activities and dual-task performance, compared to a group that only undergoes treadmill exercise.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 85
Healthy Volunteers: f
View:

• Diagnosis of Alzheimer's disease according to the NINCDS-ADRDA criteria by a neurologist,

• In the early or middle stages of the disease according to the Clinical Dementia Rating Scale (CDR),

• Receiving medical treatment for Alzheimer's disease (e.g., cholinesterase inhibitors or memantine) for at least the past month,

• Able to walk at least 400 meters in the 6-Minute Walk Test, indicating functional mobility,

• Able to read and understand instructions given in Turkish.

Locations
Other Locations
Turkey
İstanbul University-Cerrahpaşa
RECRUITING
Istanbul
Contact Information
Primary
Kübra Nur Menengiç, MSc
kmenengic@gmail.com
+90 216 547 26 00
Backup
İpek Yeldan, Prof. Dr.
ipekyeldan@gmail.com
+90 212 866 37 00
Time Frame
Start Date: 2025-08-01
Estimated Completion Date: 2027-12-01
Participants
Target number of participants: 46
Treatments
Active_comparator: Treadmill Based Training Group
In the study, for 8 weeks, the Treadmill-based Training Group will undergo walking training on a treadmill two days a week.
Experimental: Dual-Task Treadmill Based Training Group
Dual-Task Treadmill-based Training Group will receive dual-task walking training involving both motor and cognitive tasks on the treadmill for 8 week, two days in a week.
Related Therapeutic Areas
Sponsors
Leads: Istanbul University - Cerrahpasa

This content was sourced from clinicaltrials.gov