Mechanisms of Mindfulness for Cognition in Early-Stage Alzheimer's Disease

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and structure? 3. How does mindfulness affect daily function and quality of life? Researchers will compare all outcomes to one other groups. In one group, individuals will participate in a mindfulness class intervention; in the other group, individuals will not engage in any active interventions immediately, but will be placed on a waitlist for the mindfulness intervention. Researchers will compare all outcomes between the groups groups to determine whether the mindfulness interventions leads to greater improvement compared to no intervention (waitlist group). Participants will: * Be randomly assigned to participate in the mindfulness intervention, or no immediate intervention (waitlist) * Complete paper-and-pencil cognitive testing, surveys, computerized tasks, and neuroimaging measures (EEG and MRI) before and after the intervention Outcomes will be assess at baseline, 2 months, 4 months and 6 months.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 100
Healthy Volunteers: t
View:

• Healthy older adults will show cognitive performance within 1.0 SD for age \& education adjusted norms on a neuropsychological test battery

• Mild cognitive impairment (MCI) participants will show performance on delayed recall or one more or more other cognitive domains worse than 1.5 SD for age \& education adjusted norms, an MMSE score between 25-30, and a MoCA score between 20-30.

Locations
United States
Massachusetts
VA Boston Healthcare System - Jamaica Plain Campus
RECRUITING
Boston
Contact Information
Primary
Katherine W Turk, MD
ctcnbrainlab@gmail.com
8573645429
Backup
Kathy Y Xie, PhD
ctcnbrainlab@gmail.com
8572300905
Time Frame
Start Date: 2025-01-23
Estimated Completion Date: 2027-03-31
Participants
Target number of participants: 100
Treatments
Experimental: Mindfulness
MBSR course of mindfulness using focused attention, body scan practice and light chair yoga.
No_intervention: Mindfulness Waitlist
Individuals in the Mindfulness Waitlist group will not engage in any of the study interventions until 2 months has passed. Then they will be enrolled in the Mindfulness Intervention.
Related Therapeutic Areas
Sponsors
Leads: VA Boston Healthcare System

This content was sourced from clinicaltrials.gov