Grit Against Cognitive Decline in Aging and Preclinical Alzheimer's Disease

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measured with behavioral tests, as well as by taking brain images with Magnetic Resonance Imaging (MRI). Participants will come in for one baseline visit followed by 10 days of daily rTMS study visits (Monday through Friday) and an evaluation visit. Then, there will be a 2-week break. After this break, they will return for another baseline visit, an additional 10 days of rTMS, and a final evaluation visit.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 99
Healthy Volunteers: t
View:

• Between the ages of 40-99

• Native English speakers

• Willing and able to consent to the protocol and undergo imaging and neuropsychological testing at the specified time points

• Cognitively normal older adults and individuals with preclinical Alzheimer's disease will be included.

Locations
United States
Massachusetts
Massachusetts General Hospital
RECRUITING
Boston
Contact Information
Primary
Alexandra Touroutoglou, PhD
atouroutoglou@mgh.harvard.edu
6176436348
Backup
Anna Du, BA
andu@mgh.harvard.edu
6176436348
Time Frame
Start Date: 2025-04-07
Estimated Completion Date: 2029-08-31
Participants
Target number of participants: 80
Treatments
Experimental: Active TMS
All participants will receive the same study interventions in a within-subject crossover design.
Sham_comparator: Sham TMS
All participants will receive the same study interventions in a within-subject crossover design.
Related Therapeutic Areas
Sponsors
Leads: Massachusetts General Hospital

This content was sourced from clinicaltrials.gov

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