Evaluation of Ultralow Dose PET Imaging for Detecting Amyloid Tracer Uptake

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The goal of this clinical trial is to evaluate an investigational ultralow dose PET imaging technique for Alzheimer's disease, mild cognitive impairment, other forms of dementia detection and monitoring. The main question it aims to answer is: Can the investigators optimize the timing, scan duration, and image reconstruction to reduce the radiation dose 10-100 fold of the current clinical standard? Participants will be injected with a radioactive tracer called 18F-Florbetapir or 18F-Flutemetamol and be imaged on a new type of high-sensitivity PET scanner for up to 3 hours

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 120
Healthy Volunteers: t
View:

• Age ≥18 years.

• Ability to provide informed consent and comply with study procedures.

• For female participants:

‣ Must not be pregnant or breastfeeding.

⁃ Negative pregnancy test required for women of childbearing potential.

Locations
United States
New Jersey
Nuclear Imaging Institute
RECRUITING
Englewood
Contact Information
Primary
Barbara Blanchfield
bblanchfield@nii.org
973-255-4955
Time Frame
Start Date: 2025-05-20
Estimated Completion Date: 2030-06-30
Participants
Target number of participants: 200
Treatments
Other: ultralow dose imaging group
Participants will be enrolled for an ultralow dose PET scan to evaluate image quality and optimize timing and reconstruction after reducing radiation doses 10-100 fold. Participants will be injected with a very small amount of radiotracer and imaged on a PET scanner for up to 3 hours
Related Therapeutic Areas
Sponsors
Leads: Akiva Mintz

This content was sourced from clinicaltrials.gov

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