Biomarkers of the Locus Coeruleus Nucleus: Links With Early Tau Pathology, Cognition and Alzheimer's Disease Risk.
Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
Alzheimer's disease (AD) is characterized by a long-lasting silent phase. Among initial events, emergence of tau pathology in locus coeruleus (LC) brainstem nucleus, well before the one observed in medial temporal cortex, is highly relevant. LC integrity and function can be assessed in vivo with MRI and pupil measures. The current research proposes to evaluate these LC markers in an aged healthy cohort (n=100, with half APOE4 positive) and to relate these markers with cerebral tau pathology, AD risk and cognitive function.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Maximum Age: 100
Healthy Volunteers: t
View:
• Participant in the INSPIRE-T cohort
• Normal cognitive assessment
• MMSE score ≥ 27 out of 30 (Mini-Mental State Examination)
• Normal visual abilities (in corrected or uncorrected vision)
• Normal motor skills
Locations
Other Locations
France
University Hospital of Toulouse
RECRUITING
Toulouse
Contact Information
Primary
PAYOUX P Pierre, MD
payoux.p@chu-toulouse.fr
+33 (0)562746169
Backup
DELRIEU J Julien, MD
dlerieu.j@chu-toulouse.fr
+33 (0)5 61 77 70 58
Time Frame
Start Date: 2026-02-02
Estimated Completion Date: 2029-01-31
Participants
Target number of participants: 100
Treatments
Experimental: experimental arm
TEP exam, MRI exam, oculometry assessment and cognitive tasks
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Toulouse