Spatial Memory Training and Cognitive Function

Status: Recruiting
Location: See location...
Intervention Type: Other, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Mild cognitive impairment (MCI) is often considered a transitional stage between normal aging and dementia, particularly Alzheimer's disease (AD). Patients with MCI have subjective memory complaints corroborated by standard neuropsychological tests but remain functionally autonomous. One of the first brain regions to show AD pathology is the hippocampus (HPC). Reduction in HPC volume is a strong predictor of AD dementia. Therefore, improvement or restoration of HPC structure and function is thus an attractive target for improvement in memory and AD prevention strategies. In the current study, the investigators propose to examine the effects of a 3-month long spatial memory program on spatial memory and the hippocampus in patients diagnosed with MCI. Neuropsychological tests are also administered before and after the training to assess the effects of the intervention on cognition. In our previous research, the investigators have shown that spatial memory intervention program (SMIP) improves cognition and hippocampal based spatial memory compared to controls.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Healthy Volunteers: f
View:

• Age 55 years and above.

• Primary language is English or French.

• Individuals having received a diagnosis of Mild Cognitive Impairment (MCI).

Locations
Other Locations
Canada
Douglas Mental Health University Institute
RECRUITING
Verdun
Contact Information
Primary
Daniel R Saumier, PhD
Daniel.Saumier@douglas.mcgill.ca
514-761-6131
Time Frame
Start Date: 2025-06-15
Estimated Completion Date: 2030-12-30
Participants
Target number of participants: 80
Treatments
Experimental: SMIP
Spatial Memory Intervention Program
Placebo_comparator: Control
The control group will receive no intervention between baseline and follow-up.
Related Therapeutic Areas
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR)
Leads: Douglas Mental Health University Institute

This content was sourced from clinicaltrials.gov