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Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker. In people with dementia, it gets much worse, making it harder to talk with others, follow directions, or remember things like shopping lists. This may happen because brain waves that support working memory fall out of sync. Researchers can see these brain waves using a test called EEG. In this study, the investigators will try to get these brain waves back in sync using a safe, non-invasive form of brain stimulation called transcranial magnetic stimulation (TMS), and will time it to each person's brain waves to make it more effective. The goal is to improve working memory in people with dementia. If successful, dementia patients may be able to be more independent taking pressure off their families.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 55
Healthy Volunteers: f
View:

• Individuals must be diagnosed with Alzheimer's Disease or related dementias by a clinician.

• Individuals must exhibit adequate oral communication skills and cognitive function sufficient to obtain a score above 10 on the MMSE

• Instructions will be delivered in English; therefore participants must demonstrate an understanding of instruction provided in English.

• Individuals must be at least 55 years or older

Locations
Other Locations
Canada
Ivor Wynne Center
RECRUITING
Hamilton
Contact Information
Primary
Aimee Nelson
nelsonaj@mcmaster.ca
(905) 525-9140
Backup
Ameer Hamoodi
hamoodia@mcmaster.ca
Time Frame
Start Date: 2026-07-07
Estimated Completion Date: 2028-08-01
Participants
Target number of participants: 30
Treatments
Experimental: Intervention: EEG-triggered TMS
The electroencephalography (EEG) triggered transcranial magnetic stimulation (TMS) arm involves receiving TMS timed to particular phases of EEG involved in working memory. TMS involves the delivery of brief current to the part of the brain that is involved in working memory. EEG involves placing 32 electrodes on the surface of then head and reading the brain's waves in real-time. TMS will be delivered to the part of the brain involved in working memory timed to EEG recorded brain waves
Related Therapeutic Areas
Sponsors
Leads: McMaster University

This content was sourced from clinicaltrials.gov