Phonological Constraints on Language Development in Individuals With Williams Syndrome

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Williams syndrome (WS) is a neurodevelopmental disease characterized by mild to moderate intellectual disability and an extremely heterogeneous cognitive profile. Research has outlined two main features of WS: an atypical social behavior associated with surprising language abilities, and a hyperacusis. The purpose of this project is to investigate the relationships between both these abilities, and particularly the role of the hyperacusis on language abilities. The hyperacusis would be crucial in developing language skills: the apparent strength in the verbal domain could rely on Phonological Short Term Memory (PSTM) more in individuals with WS than in typically developing individuals. In addition, the investigators will compare individuals with WS to individuals with Down syndrome (DS): DS is often associated to strong limitations in the PSTM with poor language abilities. To this end, the investigators will use a highly innovative approach including physiological assessments (EEG-NIRS protocol) and questionnaires. The performance of people with WS will be compared to those of participants with DS and TD participants of same DA and cognitive assessments.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Healthy Volunteers: t
View:

• For SW and SD: genetic diagnosis and aged between 6- and 17 years old.

• For typical participants: any child, adolescent or young adult of the same developmental or chronological age (between 6 and 17 years of age)

• adult group (between 20 and 60 years).

Locations
Other Locations
France
CHU Amiens
RECRUITING
Amiens
Contact Information
Primary
Fabrice Wallois, Pr
fabrice.wallois@u-picardie.fr
33+3 22 08 77 75
Time Frame
Start Date: 2024-07-05
Estimated Completion Date: 2026-07
Participants
Target number of participants: 130
Treatments
Experimental: Patients with Williams syndrome
Active_comparator: Patients with Down syndrome
Sham_comparator: Healthy children
Active_comparator: Healthy adults
Related Therapeutic Areas
Sponsors
Leads: Centre Hospitalier Universitaire, Amiens

This content was sourced from clinicaltrials.gov