• Male or female patients aged ≥18 years with documented diagnosis of any of the following types of inherited EB: Simplex, Junctional, Dystrophic, Kindler. Enrolment will be extended to patients ≥12 years old and \<18 years old after positive opinion of a data monitoring committee after at least 4 adult patients have completed study.

• Presence of at least 1 pair of well-matched index areas. Up to 2 pairs of index areas (1 pair of non-wound and 1 pair of wound index areas) can be selected in each patient

• For non-wound itch index areas, both areas should:

‣ Have chronic itch with a score ≥40 mm on a 100 mm VAS

⁃ Not exceed 20 percent of body surface area (BSA) or be less than 1 percent of BSA

⁃ Be similar size, up to twice the area of the smaller index area

• For wound index areas, both wounds should:

‣ Have a surface area ≥5 cm\^2 and ≤50 cm\^2 inclusive and be aged ≥3 weeks

⁃ Be well matched for size (up to twice the area of the smaller index area) and age (both either ≥3 weeks to 3 months or \>3 months)

• Female patients of childbearing potential or men whose sexual partners are women of childbearing potential (WOCBP) must use highly effective birth control

• WOCBP must have a negative urine pregnancy test result at baseline

• Must provide written consent (or assent for patients aged \<18 years with parental/guardian consent)