Screening for Individual Susceptibility Factors to Immersion Pulmonary Edema

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other, Device, Biological
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Immersion Pulmonary Edema (IPE) is a relatively new form of hemodynamic pulmonary edema. The number of cases has been increasing over the last ten years and it has become the second most common cause of hospitalization for military divers, after decompression sickness. The pathophysiological mechanisms of IPE are not completely known. Its occurrence is linked to a combination of factors related to the environmental constraints of diving, as well as to the diver's equipment. The main external factors are increased hydrostatic pressure, cold, intense effort and emotional stress. The impact of internal factors is not known. At this time, no severe forms of IPE have been identified in the military. However, it is important to identify this pathology at an early stage, even if the signs appear minor, because the continuation of underwater activity can significantly worsen the clinical picture. The risk of recurrence (greater than 15%) could result in a severe or even lethal accident.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:

• Military or civilian diver with at least 100 dives

• Between the ages of 18 and 60

• Good physical condition (able to run/swim for 30 minutes at a constant pace).

Locations
Other Locations
France
Equipe Résidente de Recherche Subaquatique Opérationnelle
RECRUITING
Toulon
Hôpital d'Instruction des Armées Sainte-Anne
RECRUITING
Toulon
Contact Information
Primary
CASTAGNA Olivier, MD, PhD
olivier.castagna@intradef.gouv.fr
483162830
Time Frame
Start Date: 2022-08-17
Estimated Completion Date: 2026-08
Participants
Target number of participants: 63
Treatments
Active_comparator: History of Immersion Pulmonary Edema
The participants will have 2 visits:~At visit 1 (Day 0), the participants will perform a terrestrial exercise, have a transthoracic cardiac ultrasound, a transthoracic pulmonary ultrasound and several blood samples will be collected.~At visit 2 (Day 7), the participants will perform a swimming exercise, have a transthoracic cardiac ultrasound, a transthoracic pulmonary ultrasound and several blood samples will be collected.
Active_comparator: No history of Immersion Pulmonary Edema
The participants will have 2 visits:~At visit 1 (Day 0), the participants will perform a terrestrial exercise, have a transthoracic cardiac ultrasound, a transthoracic pulmonary ultrasound and several blood samples will be collected.~At visit 2 (Day 7), the participants will perform a swimming exercise, have a transthoracic cardiac ultrasound, a transthoracic pulmonary ultrasound and several blood samples will be collected.
Related Therapeutic Areas
Sponsors
Leads: Direction Centrale du Service de Santé des Armées

This content was sourced from clinicaltrials.gov