IZABRIGHT-Lung01: A Randomized, Open-label, Phase 2/3 Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Disease Progression on EGFR Tyrosine Kinase Inhibitor Therapy
Status: Recruiting
Location: See all (186) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Non-squamous NSCLC, not amenable to treatment in curative intent.
• Documented evidence of EGFR mutation (exon 19 deletion, L858R mutation).
• Progressive disease on a 3rd-generation (such as osimertinib, furmonertinib, lazertinib,...) EGFR-TKI-based mono- or combination therapy regimen as the most recent line of therapy in an adjuvant, locally advanced, or metastatic treatment setting.
• Eligible to receive a platinum-based doublet chemotherapy regimen (either cisplatin or carboplatin in combination with pemetrexed).
Locations
United States
California
Local Institution - 0279
NOT_YET_RECRUITING
Irvine
Local Institution - 0154
NOT_YET_RECRUITING
Orange
Colorado
Shaw Cancer Center
RECRUITING
Edwards
Florida
Local Institution - 0085
WITHDRAWN
Gainesville
Local Institution - 0142
NOT_YET_RECRUITING
Pembroke Pines
Georgia
Piedmont Healthcare
RECRUITING
Atlanta
John B Amos Cancer Center
RECRUITING
Columbus
Illinois
Local Institution - 0153
NOT_YET_RECRUITING
Chicago
Massachusetts
Dana-Farber Cancer Institute
RECRUITING
Boston
Missouri
Washington University School of Medicine
RECRUITING
St Louis
Nevada
Renown Regional Medical Center
RECRUITING
Reno
New York
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
RECRUITING
Mineola
Local Institution - 0158
NOT_YET_RECRUITING
New York
NYU Langone Health
RECRUITING
New York
Rochester General Hospital Infectious Disease
RECRUITING
Rochester
Ohio
University Hospitals Cleveland Medical Center
RECRUITING
Cleveland
Local Institution - 0284
NOT_YET_RECRUITING
Columbus
Oregon
Local Institution - 0171
NOT_YET_RECRUITING
Portland
Providence Cancer Institute Franz Clinic
RECRUITING
Portland
Providence St. Vincent Medical Center
RECRUITING
Portland
Pennsylvania
Hospital of the University of Pennsylvania
RECRUITING
Philadelphia
Local Institution - 0088
NOT_YET_RECRUITING
Pittsburgh
Tennessee
Local Institution - 0268
WITHDRAWN
Chattanooga
Tennessee Oncology
RECRUITING
Nashville
Texas
Local Institution - 0025
NOT_YET_RECRUITING
Houston
Local Institution - 0173
NOT_YET_RECRUITING
San Antonio
Virginia
University of Virginia Health System
RECRUITING
Charlottesville
Virginia Commonwealth University (Vcu)
RECRUITING
Richmond
Other Locations
Argentina
Local Institution - 0004
NOT_YET_RECRUITING
Abb
Local Institution - 0008
NOT_YET_RECRUITING
Ciudad Autónoma De Buenos Aires
Local Institution - 0094
NOT_YET_RECRUITING
Córdoba
Belgium
Local Institution - 0161
NOT_YET_RECRUITING
Auderghem
Local Institution - 0023
NOT_YET_RECRUITING
Ghent
Local Institution - 0024
NOT_YET_RECRUITING
Sint-niklaas
Local Institution - 0280
NOT_YET_RECRUITING
Wilrijk
Local Institution - 0022
NOT_YET_RECRUITING
Yvoir
Canada
Local Institution - 0190
NOT_YET_RECRUITING
Calgary
Local Institution - 0184
NOT_YET_RECRUITING
Chicoutimi
Local Institution - 0185
NOT_YET_RECRUITING
Montreal
Princess Margaret Cancer Centre
RECRUITING
Toronto
Chile
Local Institution - 0005
NOT_YET_RECRUITING
Santiago
Local Institution - 0006
NOT_YET_RECRUITING
Santiago
Local Institution - 0007
NOT_YET_RECRUITING
Santiago
China
Local Institution - 0271
NOT_YET_RECRUITING
Anyang
Local Institution - 0244
NOT_YET_RECRUITING
Beijing
Local Institution - 0246
NOT_YET_RECRUITING
Changchun
Local Institution - 0255
NOT_YET_RECRUITING
Changsha
Local Institution - 0259
NOT_YET_RECRUITING
Chongqing
Fujian Cancer Hospital
RECRUITING
Fuzhou
Local Institution - 0252
NOT_YET_RECRUITING
Hangzhou
Jiangmen Center Hospital
RECRUITING
Jiangmen
Local Institution - 0248
NOT_YET_RECRUITING
Jinan
Local Institution - 0267
NOT_YET_RECRUITING
Jingzhou
Local Institution - 0251
NOT_YET_RECRUITING
Linhai
Local Institution - 0261
NOT_YET_RECRUITING
Luoyang
Local Institution - 0247
NOT_YET_RECRUITING
Nanchang
Local Institution - 0260
NOT_YET_RECRUITING
Nanning
Local Institution - 0249
NOT_YET_RECRUITING
Shanghai
Local Institution - 0250
NOT_YET_RECRUITING
Shanghai
Local Institution - 0257
NOT_YET_RECRUITING
Shenyang
Shanxi Cancer Hospital
RECRUITING
Taiyuan
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
RECRUITING
Wuhan
Local Institution - 0256
NOT_YET_RECRUITING
Xuzhou
Colombia
Local Institution - 0228
NOT_YET_RECRUITING
Bogotá
Local Institution - 0226
NOT_YET_RECRUITING
Cali
Local Institution - 0227
NOT_YET_RECRUITING
Montería
Local Institution - 0229
NOT_YET_RECRUITING
Valledupar
France
Local Institution - 0162
NOT_YET_RECRUITING
Bron
Local Institution - 0018
NOT_YET_RECRUITING
La Tronche
Local Institution - 0010
NOT_YET_RECRUITING
Lille
Local Institution - 0012
NOT_YET_RECRUITING
Marseille
Local Institution - 0278
NOT_YET_RECRUITING
Nantes
Local Institution - 0011
NOT_YET_RECRUITING
Paris
Local Institution - 0015
NOT_YET_RECRUITING
Paris
Local Institution - 0170
NOT_YET_RECRUITING
Saint-herblain
Local Institution - 0014
NOT_YET_RECRUITING
Strasbourg
Local Institution - 0017
NOT_YET_RECRUITING
Toulouse
Local Institution - 0019
NOT_YET_RECRUITING
Villejuif
Germany
Local Institution - 0211
NOT_YET_RECRUITING
Berlin
Local Institution - 0208
NOT_YET_RECRUITING
Chemnitz
Local Institution - 0213
NOT_YET_RECRUITING
Cologne
Local Institution - 0236
NOT_YET_RECRUITING
Donauwörth
Local Institution - 0207
NOT_YET_RECRUITING
Esslingen Am Neckar
Local Institution - 0238
NOT_YET_RECRUITING
Esslingen Am Neckar
Local Institution - 0215
NOT_YET_RECRUITING
Gauting
Local Institution - 0242
NOT_YET_RECRUITING
Hamburg
Local Institution - 0210
NOT_YET_RECRUITING
Heidelberg
Local Institution - 0239
NOT_YET_RECRUITING
Kassel
Local Institution - 0274
NOT_YET_RECRUITING
Kiel
Local Institution - 0209
NOT_YET_RECRUITING
Oldenburg
Local Institution - 0212
NOT_YET_RECRUITING
Stuttgart
Local Institution - 0241
NOT_YET_RECRUITING
Ulm
Greece
Local Institution - 0054
NOT_YET_RECRUITING
Athens
Local Institution - 0060
NOT_YET_RECRUITING
Chaïdári
Local Institution - 0056
NOT_YET_RECRUITING
Thessaloniki
Local Institution - 0062
NOT_YET_RECRUITING
Thessaloniki
India
Local Institution - 0073
NOT_YET_RECRUITING
Ahmedabad
Local Institution - 0083
WITHDRAWN
Ahmedabad
Local Institution - 0069
NOT_YET_RECRUITING
Bengaluru
Local Institution - 0072
WITHDRAWN
Gurugram
Local Institution - 0078
WITHDRAWN
Howrah
Local Institution - 0071
NOT_YET_RECRUITING
Mumbai
Local Institution - 0077
NOT_YET_RECRUITING
Mumbai
Local Institution - 0097
NOT_YET_RECRUITING
Nagpur
Local Institution - 0070
NOT_YET_RECRUITING
New Delhi
Italy
Local Institution - 0137
NOT_YET_RECRUITING
Avellino
Local Institution - 0036
NOT_YET_RECRUITING
Aviano
Local Institution - 0277
NOT_YET_RECRUITING
Candiolo
Local Institution - 0032
NOT_YET_RECRUITING
Milan
Local Institution - 0034
NOT_YET_RECRUITING
Naples
Local Institution - 0031
NOT_YET_RECRUITING
Orbassano
Local Institution - 0029
NOT_YET_RECRUITING
Parma
Local Institution - 0028
NOT_YET_RECRUITING
Ravenna
Japan
Local Institution - 0197
NOT_YET_RECRUITING
Hamamatsu
Local Institution - 0198
NOT_YET_RECRUITING
Hirakata
Local Institution - 0194
WITHDRAWN
Ina-machi
Local Institution - 0191
NOT_YET_RECRUITING
Kashiwa
Local Institution - 0202
NOT_YET_RECRUITING
Koto-ku
Local Institution - 0200
NOT_YET_RECRUITING
Kurashiki
Local Institution - 0201
NOT_YET_RECRUITING
Kurume
Local Institution - 0195
NOT_YET_RECRUITING
Nagaizumi-cho,sunto-gun
Local Institution - 0196
NOT_YET_RECRUITING
Nagoya
Local Institution - 0199
NOT_YET_RECRUITING
Nishinomiya
Local Institution - 0204
NOT_YET_RECRUITING
Ōsaka-sayama
Local Institution - 0217
NOT_YET_RECRUITING
Sapporo
Local Institution - 0192
NOT_YET_RECRUITING
Sendai
Local Institution - 0203
NOT_YET_RECRUITING
Tōon
Local Institution - 0193
NOT_YET_RECRUITING
Yokohama
Mexico
Local Institution - 0222
NOT_YET_RECRUITING
Chihuahua City
Local Institution - 0223
NOT_YET_RECRUITING
Mexico City
Local Institution - 0225
NOT_YET_RECRUITING
Mexico City
Local Institution - 0224
NOT_YET_RECRUITING
Oaxaca City
Netherlands
Local Institution - 0164
NOT_YET_RECRUITING
Amsterdam
Local Institution - 0216
NOT_YET_RECRUITING
Amsterdam
Local Institution - 0163
NOT_YET_RECRUITING
Harderwijk
Norway
Local Institution - 0106
NOT_YET_RECRUITING
Bergen
Local Institution - 0103
NOT_YET_RECRUITING
Drammen
Local Institution - 0105
NOT_YET_RECRUITING
Oslo
Poland
Local Institution - 0219
NOT_YET_RECRUITING
Bydgoszcz
Local Institution - 0231
NOT_YET_RECRUITING
Gdynia
Local Institution - 0220
NOT_YET_RECRUITING
Lublin
Republic of Korea
Local Institution - 0089
NOT_YET_RECRUITING
Cheongju-si
Local Institution - 0043
NOT_YET_RECRUITING
Goyang-si
Local Institution - 0044
NOT_YET_RECRUITING
Seongnam
Local Institution - 0042
NOT_YET_RECRUITING
Seoul
Local Institution - 0045
NOT_YET_RECRUITING
Seoul
Local Institution - 0092
NOT_YET_RECRUITING
Seoul
Local Institution - 0095
NOT_YET_RECRUITING
Seoul
Local Institution - 0046
NOT_YET_RECRUITING
Suwon
Romania
Local Institution - 0115
NOT_YET_RECRUITING
Bucharest
Local Institution - 0120
NOT_YET_RECRUITING
Bucharest
Local Institution - 0123
NOT_YET_RECRUITING
Bucharest
Local Institution - 0133
NOT_YET_RECRUITING
Cluj-napoca
Local Institution - 0130
NOT_YET_RECRUITING
Craiova
Local Institution - 0132
NOT_YET_RECRUITING
Florești
Local Institution - 0119
NOT_YET_RECRUITING
Iași
Local Institution - 0124
NOT_YET_RECRUITING
Iași
Singapore
Local Institution - 0262
NOT_YET_RECRUITING
Singapore
Local Institution - 0263
NOT_YET_RECRUITING
Singapore
Spain
Local Institution - 0177
NOT_YET_RECRUITING
Barcelona
Local Institution - 0218
NOT_YET_RECRUITING
Barcelona
Local Institution - 0175
NOT_YET_RECRUITING
Madrid
Local Institution - 0176
NOT_YET_RECRUITING
Madrid
Local Institution - 0206
NOT_YET_RECRUITING
Madrid
Local Institution - 0181
NOT_YET_RECRUITING
Majadahonda
Local Institution - 0178
NOT_YET_RECRUITING
Málaga
Local Institution - 0182
NOT_YET_RECRUITING
Seville
Local Institution - 0180
NOT_YET_RECRUITING
Valencia
Local Institution - 0179
NOT_YET_RECRUITING
Zaragoza
Switzerland
Kantonsspital Baden
RECRUITING
Baden
Local Institution - 0189
NOT_YET_RECRUITING
Bellinzona
Cantonal Hospital St.Gallen
RECRUITING
Sankt Gallen
Taiwan
E-Da hospital
RECRUITING
Kaohsiung City
Taichung Veterans General Hospital
RECRUITING
Taichung
National Cheng Kung University Hospital
RECRUITING
Tainan
National Taiwan University Hospital
RECRUITING
Taipei
Taipei Medical University Hospital
RECRUITING
Taipei
Taipei Veterans General Hospital
RECRUITING
Taipei
Thailand
Local Institution - 0264
NOT_YET_RECRUITING
Bangkok
Local Institution - 0265
NOT_YET_RECRUITING
Bangkok
Local Institution - 0272
NOT_YET_RECRUITING
Mueng
Local Institution - 0266
NOT_YET_RECRUITING
Songkhla
United Kingdom
Local Institution - 0110
NOT_YET_RECRUITING
Glasgow
Local Institution - 0061
NOT_YET_RECRUITING
London
Local Institution - 0140
NOT_YET_RECRUITING
London
Local Institution - 0281
NOT_YET_RECRUITING
Sulton, Surrey
Contact Information
Primary
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
Clinical.Trials@bms.com
855-907-3286
Backup
First line of the email MUST contain NCT # and Site #.
Time Frame
Start Date: 2025-11-05
Estimated Completion Date: 2031-05-15
Participants
Target number of participants: 596
Treatments
Experimental: Arm A
Experimental: Arm B
Active_comparator: Arm C
Experimental: Arm D
Active_comparator: Arm E
Related Therapeutic Areas
Sponsors
Leads: Bristol-Myers Squibb