IZABRIGHT-Lung01: A Randomized, Open-label, Phase 2/3 Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Disease Progression on EGFR Tyrosine Kinase Inhibitor Therapy
Status: Recruiting
Location: See all (184) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Non-squamous NSCLC, not amenable to treatment in curative intent.
• Documented evidence of EGFR mutation (exon 19 deletion, L858R mutation).
• Progressive disease on a 3rd-generation (such as osimertinib, furmonertinib, lazertinib,...) EGFR-TKI-based mono- or combination therapy regimen as the most recent line of therapy in an adjuvant, locally advanced, or metastatic treatment setting.
• Eligible to receive a platinum-based doublet chemotherapy regimen (either cisplatin or carboplatin in combination with pemetrexed).
Locations
United States
California
Local Institution - 0279
NOT_YET_RECRUITING
Irvine
Local Institution - 0154
NOT_YET_RECRUITING
Orange
Colorado
Local Institution - 0139
NOT_YET_RECRUITING
Edwards
Florida
Local Institution - 0085
WITHDRAWN
Gainesville
Georgia
Local Institution - 0270
NOT_YET_RECRUITING
Atlanta
Local Institution - 0143
NOT_YET_RECRUITING
Columbus
Illinois
Local Institution - 0153
NOT_YET_RECRUITING
Chicago
Massachusetts
Dana-Farber Cancer Institute
RECRUITING
Boston
Missouri
Local Institution - 0091
NOT_YET_RECRUITING
St Louis
Nevada
Local Institution - 0276
NOT_YET_RECRUITING
Reno
New York
Local Institution - 0269
NOT_YET_RECRUITING
Mineola
Local Institution - 0090
NOT_YET_RECRUITING
New York
Local Institution - 0158
NOT_YET_RECRUITING
New York
Local Institution - 0186
NOT_YET_RECRUITING
Rochester
Ohio
Local Institution - 0087
NOT_YET_RECRUITING
Cleveland
Oregon
Local Institution - 0038
NOT_YET_RECRUITING
Portland
Local Institution - 0171
NOT_YET_RECRUITING
Portland
Local Institution - 0275
NOT_YET_RECRUITING
Portland
Pennsylvania
Local Institution - 0205
NOT_YET_RECRUITING
Philadelphia
Local Institution - 0088
NOT_YET_RECRUITING
Pittsburgh
Tennessee
Local Institution - 0268
NOT_YET_RECRUITING
Chattanooga
Local Institution - 0093
NOT_YET_RECRUITING
Nashville
Texas
Local Institution - 0025
NOT_YET_RECRUITING
Houston
Local Institution - 0173
NOT_YET_RECRUITING
San Antonio
Virginia
University of Virginia Health System
RECRUITING
Charlottesville
Local Institution - 0138
NOT_YET_RECRUITING
Richmond
Other Locations
Argentina
Local Institution - 0004
NOT_YET_RECRUITING
Abb
Local Institution - 0008
NOT_YET_RECRUITING
Ciudad Autónoma De Buenos Aires
Local Institution - 0094
NOT_YET_RECRUITING
Córdoba
Belgium
Local Institution - 0161
NOT_YET_RECRUITING
Auderghem
Local Institution - 0023
NOT_YET_RECRUITING
Ghent
Local Institution - 0024
NOT_YET_RECRUITING
Sint-niklaas
Local Institution - 0280
NOT_YET_RECRUITING
Wilrijk
Local Institution - 0022
NOT_YET_RECRUITING
Yvoir
Canada
Local Institution - 0190
NOT_YET_RECRUITING
Calgary
Local Institution - 0184
NOT_YET_RECRUITING
Chicoutimi
Local Institution - 0185
NOT_YET_RECRUITING
Montreal
Local Institution - 0183
NOT_YET_RECRUITING
Toronto
Chile
Local Institution - 0005
NOT_YET_RECRUITING
Santiago
Local Institution - 0006
NOT_YET_RECRUITING
Santiago
Local Institution - 0007
NOT_YET_RECRUITING
Santiago
China
Local Institution - 0271
NOT_YET_RECRUITING
Anyang
Local Institution - 0244
NOT_YET_RECRUITING
Beijing
Local Institution - 0246
NOT_YET_RECRUITING
Changchun
Local Institution - 0255
NOT_YET_RECRUITING
Changsha
Local Institution - 0259
NOT_YET_RECRUITING
Chongqing
Local Institution - 0253
NOT_YET_RECRUITING
Fuzhou
Local Institution - 0252
NOT_YET_RECRUITING
Hangzhou
Local Institution - 0245
NOT_YET_RECRUITING
Jiangmen
Local Institution - 0248
NOT_YET_RECRUITING
Jinan
Local Institution - 0267
NOT_YET_RECRUITING
Jingzhou
Local Institution - 0251
NOT_YET_RECRUITING
Linhai
Local Institution - 0261
NOT_YET_RECRUITING
Luoyang
Local Institution - 0247
NOT_YET_RECRUITING
Nanchang
Local Institution - 0260
NOT_YET_RECRUITING
Nanning
Local Institution - 0249
NOT_YET_RECRUITING
Shanghai
Local Institution - 0250
NOT_YET_RECRUITING
Shanghai
Local Institution - 0257
NOT_YET_RECRUITING
Shenyang
Local Institution - 0258
NOT_YET_RECRUITING
Taiyuan
Local Institution - 0243
NOT_YET_RECRUITING
Wuhan
Local Institution - 0256
NOT_YET_RECRUITING
Xuzhou
Colombia
Local Institution - 0228
NOT_YET_RECRUITING
Bogotá
Local Institution - 0226
NOT_YET_RECRUITING
Cali
Local Institution - 0227
NOT_YET_RECRUITING
Montería
Local Institution - 0229
NOT_YET_RECRUITING
Valledupar
France
Local Institution - 0162
NOT_YET_RECRUITING
Bron
Local Institution - 0018
NOT_YET_RECRUITING
La Tronche
Local Institution - 0010
NOT_YET_RECRUITING
Lille
Local Institution - 0012
NOT_YET_RECRUITING
Marseille
Local Institution - 0278
NOT_YET_RECRUITING
Nantes
Local Institution - 0011
NOT_YET_RECRUITING
Paris
Local Institution - 0015
NOT_YET_RECRUITING
Paris
Local Institution - 0170
NOT_YET_RECRUITING
Saint-herblain
Local Institution - 0014
NOT_YET_RECRUITING
Strasbourg
Local Institution - 0017
NOT_YET_RECRUITING
Toulouse
Local Institution - 0019
NOT_YET_RECRUITING
Villejuif
Germany
Local Institution - 0211
NOT_YET_RECRUITING
Berlin
Local Institution - 0208
NOT_YET_RECRUITING
Chemnitz
Local Institution - 0213
NOT_YET_RECRUITING
Cologne
Local Institution - 0236
NOT_YET_RECRUITING
Donauwörth
Local Institution - 0207
NOT_YET_RECRUITING
Esslingen Am Neckar
Local Institution - 0238
NOT_YET_RECRUITING
Esslingen Am Neckar
Local Institution - 0215
NOT_YET_RECRUITING
Gauting
Local Institution - 0242
NOT_YET_RECRUITING
Hamburg
Local Institution - 0210
NOT_YET_RECRUITING
Heidelberg
Local Institution - 0239
NOT_YET_RECRUITING
Kassel
Local Institution - 0274
NOT_YET_RECRUITING
Kiel
Local Institution - 0209
NOT_YET_RECRUITING
Oldenburg
Local Institution - 0212
NOT_YET_RECRUITING
Stuttgart
Local Institution - 0241
NOT_YET_RECRUITING
Ulm
Greece
Local Institution - 0054
NOT_YET_RECRUITING
Athens
Local Institution - 0060
NOT_YET_RECRUITING
Chaïdári
Local Institution - 0056
NOT_YET_RECRUITING
Thessaloniki
Local Institution - 0062
NOT_YET_RECRUITING
Thessaloniki
India
Local Institution - 0073
NOT_YET_RECRUITING
Ahmedabad
Local Institution - 0083
WITHDRAWN
Ahmedabad
Local Institution - 0069
NOT_YET_RECRUITING
Bengaluru
Local Institution - 0072
WITHDRAWN
Gurugram
Local Institution - 0078
WITHDRAWN
Howrah
Local Institution - 0071
NOT_YET_RECRUITING
Mumbai
Local Institution - 0077
NOT_YET_RECRUITING
Mumbai
Local Institution - 0097
NOT_YET_RECRUITING
Nagpur
Local Institution - 0070
NOT_YET_RECRUITING
New Delhi
Italy
Local Institution - 0137
NOT_YET_RECRUITING
Avellino
Local Institution - 0036
NOT_YET_RECRUITING
Aviano
Local Institution - 0277
NOT_YET_RECRUITING
Candiolo
Local Institution - 0032
NOT_YET_RECRUITING
Milan
Local Institution - 0034
NOT_YET_RECRUITING
Napoli
Local Institution - 0031
NOT_YET_RECRUITING
Orbassano
Local Institution - 0029
NOT_YET_RECRUITING
Parma
Local Institution - 0028
NOT_YET_RECRUITING
Ravenna
Japan
Local Institution - 0197
NOT_YET_RECRUITING
Hamamatsu
Local Institution - 0198
NOT_YET_RECRUITING
Hirakata
Local Institution - 0194
NOT_YET_RECRUITING
Ina-machi
Local Institution - 0191
NOT_YET_RECRUITING
Kashiwa
Local Institution - 0202
NOT_YET_RECRUITING
Koto-ku
Local Institution - 0200
NOT_YET_RECRUITING
Kurashiki
Local Institution - 0201
NOT_YET_RECRUITING
Kurume
Local Institution - 0195
NOT_YET_RECRUITING
Nagaizumi-cho,sunto-gun
Local Institution - 0196
NOT_YET_RECRUITING
Nagoya
Local Institution - 0199
NOT_YET_RECRUITING
Nishinomiya
Local Institution - 0204
NOT_YET_RECRUITING
Ōsaka-sayama
Local Institution - 0217
NOT_YET_RECRUITING
Sapporo
Local Institution - 0192
NOT_YET_RECRUITING
Sendai
Local Institution - 0203
NOT_YET_RECRUITING
Tōon
Local Institution - 0193
NOT_YET_RECRUITING
Yokohama
Mexico
Local Institution - 0222
NOT_YET_RECRUITING
Chihuahua City
Local Institution - 0223
NOT_YET_RECRUITING
Mexico City
Local Institution - 0225
NOT_YET_RECRUITING
Mexico City
Local Institution - 0224
NOT_YET_RECRUITING
Oaxaca City
Netherlands
Local Institution - 0164
NOT_YET_RECRUITING
Amsterdam
Local Institution - 0216
NOT_YET_RECRUITING
Amsterdam
Local Institution - 0163
NOT_YET_RECRUITING
Harderwijk
Norway
Local Institution - 0106
NOT_YET_RECRUITING
Bergen
Local Institution - 0103
NOT_YET_RECRUITING
Drammen
Local Institution - 0105
NOT_YET_RECRUITING
Oslo
Poland
Local Institution - 0219
NOT_YET_RECRUITING
Bydgoszcz
Local Institution - 0231
NOT_YET_RECRUITING
Gdynia
Local Institution - 0220
NOT_YET_RECRUITING
Lublin
Republic of Korea
Local Institution - 0089
NOT_YET_RECRUITING
Cheongju-si
Local Institution - 0043
NOT_YET_RECRUITING
Goyang-si
Local Institution - 0044
NOT_YET_RECRUITING
Seongnam
Local Institution - 0042
NOT_YET_RECRUITING
Seoul
Local Institution - 0045
NOT_YET_RECRUITING
Seoul
Local Institution - 0092
NOT_YET_RECRUITING
Seoul
Local Institution - 0095
NOT_YET_RECRUITING
Seoul
Local Institution - 0046
NOT_YET_RECRUITING
Suwon
Romania
Local Institution - 0115
NOT_YET_RECRUITING
Bucharest
Local Institution - 0120
NOT_YET_RECRUITING
Bucharest
Local Institution - 0123
NOT_YET_RECRUITING
Bucharest
Local Institution - 0133
NOT_YET_RECRUITING
Cluj-napoca
Local Institution - 0130
NOT_YET_RECRUITING
Craiova
Local Institution - 0132
NOT_YET_RECRUITING
Florești
Local Institution - 0119
NOT_YET_RECRUITING
Iași
Local Institution - 0124
NOT_YET_RECRUITING
Iași
Singapore
Local Institution - 0262
NOT_YET_RECRUITING
Singapore
Local Institution - 0263
NOT_YET_RECRUITING
Singapore
Spain
Local Institution - 0177
NOT_YET_RECRUITING
Barcelona
Local Institution - 0218
NOT_YET_RECRUITING
Barcelona
Local Institution - 0175
NOT_YET_RECRUITING
Madrid
Local Institution - 0176
NOT_YET_RECRUITING
Madrid
Local Institution - 0206
NOT_YET_RECRUITING
Madrid
Local Institution - 0181
NOT_YET_RECRUITING
Majadahonda
Local Institution - 0178
NOT_YET_RECRUITING
Málaga
Local Institution - 0182
NOT_YET_RECRUITING
Seville
Local Institution - 0180
NOT_YET_RECRUITING
Valencia
Local Institution - 0179
NOT_YET_RECRUITING
Zaragoza
Switzerland
Local Institution - 0188
NOT_YET_RECRUITING
Baden
Local Institution - 0189
NOT_YET_RECRUITING
Bellinzona
Cantonal Hospital St.Gallen
RECRUITING
Sankt Gallen
Taiwan
Local Institution - 0053
NOT_YET_RECRUITING
Kaohsiung City
Local Institution - 0050
NOT_YET_RECRUITING
Taichung
Local Institution - 0049
NOT_YET_RECRUITING
Tainan
Local Institution - 0048
NOT_YET_RECRUITING
Taipei
Local Institution - 0160
NOT_YET_RECRUITING
Taipei
Taipei Medical University Hospital
RECRUITING
Taipei
Thailand
Local Institution - 0264
NOT_YET_RECRUITING
Bangkok
Local Institution - 0265
NOT_YET_RECRUITING
Bangkok
Local Institution - 0272
NOT_YET_RECRUITING
Mueng
Local Institution - 0266
NOT_YET_RECRUITING
Songkhla
United Kingdom
Local Institution - 0110
NOT_YET_RECRUITING
Glasgow
Local Institution - 0061
NOT_YET_RECRUITING
London
Local Institution - 0140
NOT_YET_RECRUITING
London
Local Institution - 0281
NOT_YET_RECRUITING
Sulton, Surrey
Contact Information
Primary
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
Clinical.Trials@bms.com
8559073286
Backup
First line of the email MUST contain the NCT# and Site#
Time Frame
Start Date: 2025-11-05
Estimated Completion Date: 2031-05-15
Participants
Target number of participants: 596
Treatments
Experimental: Arm A
Experimental: Arm B
Active_comparator: Arm C
Experimental: Arm D
Active_comparator: Arm E
Related Therapeutic Areas
Sponsors
Leads: Bristol-Myers Squibb