Inter-lobar Fissure Completion as a Salvage Treatment in Patients With Failed Bronchoscopic Lung Volume Reduction
The purpose of this protocol is to perform a pilot prospective controlled clinical trial to evaluate the potential role of lung fissure completion with pleural adhesiolysis strategy (experimental intervention) in severe emphysema/COPD patients with failed bronchoscopic lung volume reduction (BLVR) via the use of endobronchial valves (EBVs) therapy. In select patients, the lung fissure completion with adhesiolysis strategy will be performed by video-assisted thoracoscopic surgery (VATS) guided stapling along the lung fissures to reduce collateral ventilation with adhesions removal and determine whether this experimental strategy will improve outcomes after failed BLVR in patients with severe emphysema/COPD.
• Age 40 to 75 years.
• Stable with less than 10mg prednisone (or equivalent) daily.
• Nonsmoking for 4 months prior to screening and willing to not smoke during the study duration.
• Current pneumococcus vaccination.
• Current influenza vaccination.
• Target lung volume reduction \<350ml after bronchoscopic lung volume reduction (BLVR).
• Persistent dyspnea defined as an mMRC score greater or equal to 2 after bronchoscopic lung volume reduction (BLVR).
• Endobronchial valves (EBV) are still in place.
• Willing and able to complete protocol required study follow-up assessments and procedures.