Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Status: Recruiting
Location: See all (5) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material. For this reason, it is thought that flushing the chest drain with saline solution, can help maintain the patency of the tube. This proposed study will evaluate the impact of regular chest drain flushing on the length of time to chest tube removal and total hospitalization as well as improvement in chest imaging and the need for additional interventions on the infected space.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients with complicated parapneumonic pleural effusion and empyema requiring chest tube placement as standard of care for inpatient management of their pleural space infection with or without intrapleural tissue plasminogen activator and deoxyribonuclease therapy

• Age \> 18 years old.

Locations
United States
Michigan
Henry Ford
RECRUITING
Sterling Heights
Nebraska
Creighton University
RECRUITING
Omaha
New York
Mount Sinai
RECRUITING
New York
Tennessee
Vanderbilt University Medical Center
RECRUITING
Nashville
Virginia
Virginia Commonwealth University
RECRUITING
Richmond
Contact Information
Primary
Samira Shojaee, MD, MPH
samira.shojaee@vumc.org
615-322-2386
Backup
Jennifer Duke, MD
jennifer.duke@vumc.org
615-322-2386
Time Frame
Start Date: 2024-06-21
Estimated Completion Date: 2026-03-30
Participants
Target number of participants: 96
Treatments
Experimental: Saline Intervention Arm
Patient will receive 20 mL sterile saline flushes into their catheter by study team members every 6 ± 2 hours. If patients are receiving intrapleural tissue plasminogen activator and deoxyribonuclease therapy, each treatment will be considered one flush.
No_intervention: No Intervention Arm
Patient will receive a saline flush as needed, to restore patency of a chest tube considered blocked. No routine flushes will be administered.
Related Therapeutic Areas
Sponsors
Leads: Vanderbilt University Medical Center

This content was sourced from clinicaltrials.gov