• The pathological types are consistent with:

‣ Atypical endometrial hyperplasia;

⁃ Patients with highly differentiated endometrioid adenocarcinoma, stage IA, and pelvic and abdominal MRI before treatment excluded deep muscle infiltration, cervical involvement, and extrauterine metastasis;

⁃ There is a strong need to preserve reproductive function; Age ≤45 years old;

⁃ Progesterone resistant patients predicted by the progesterone sensitivity prediction model (NCT05647109) established by our team in the previous study of endometrial cancer were prospectively randomized; The predicted progesterone sensitive patients were prospectively observed;

⁃ Informed consent and signed informed consent;

⁃ have follow-up conditions and are willing to continue to follow the visitors in the hospital;

⁃ Patients with normal/abnormal blood lipids who have not taken any lipid-lowering drugs;

⁃ A. Newly treated patients: did not use any nursery therapy drugs (progesterone, GNRH-a); B. 1 course of treatment (12 weeks) the lesions persisted; C. Partial remission for 2 courses of treatment (24 weeks);