Molecular Classification in Mexican Patients With Endometrial Cancer and Its Impact on Prognosis

Status: Recruiting
Location: See location...
Intervention Type: Genetic
Study Type: Observational
SUMMARY

Endometrial cancer (EC) is one of the most common gynecological neoplasms, being the second in incidence and third in mortality in Mexico. Recent studies show that EC molecular classification (Cancer Genome Atlas Research Network, 2013) serves to establish a more accurate prognosis in these patients and regulate therapeutic behavior in a personalized manner. However, there are no studies on EC molecular classification in Mexican women or its impact on prognosis and the possible modification of targeted treatment. The investigators will determine the molecular classification in EC by next-generation sequencing (NGS) to detect TP53 and POLE somatic mutations, and immunohistochemical detection of microsatellite instability (MSH2, MLH1, PMS1, PMS2, MSH6, and MSH3) in a cohort of patients with endometrioid-type EC, endometrioid subtype, attended at the Instituto Nacional de Cancerología - Mexico (INCan) and determine its impact on clinical prognosis.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
View:

• Clinical diagnosis of endometrioid-type endometrial cancer with samples available

• That the patients have undergone surgery at INCan.

Locations
Other Locations
Mexico
Instituto Nacional de Cancerología
RECRUITING
Mexico City
Contact Information
Primary
David F Cantu-de-León, PhD
dfcantu@gmail.com
+52-55-5628-0400
Backup
Diddier Prada, PhD
pradadiddier@gmail.com
+52-55-41-42-18-02
Time Frame
Start Date: 2024-03-01
Estimated Completion Date: 2027-02-01
Participants
Target number of participants: 64
Treatments
Patients with EC endometroid
Patients with EC endometroid subtype and peripheral blood, treated during 2015-2019 at the INCan.
Related Therapeutic Areas
Sponsors
Leads: National Institute of Cancerología
Collaborators: GlaxoSmithKline

This content was sourced from clinicaltrials.gov