A Case-control Study of the Clinical Utility of DNA Methylation Testing in Patient-collected Vaginal and Urine Samples: A Novel, Patient-friendly and Simple Diagnostic Solution to Detect Endometrial Cancer.
The goal of this observational case-control study is to investigate the use of DNA-methylation testing in patient-collected urine and vaginal samples to detect endometrial cancer. The study aims to answer the following questions: * Can DNA methylation testing in vaginal and full-void urine samples distinguish endometrial cancer cases from healthy controls? Researchers will compare patient-collected urine and vaginal samples from patients with diagnosed endometrial cancer (cases) to gynaecologically and oncologically healthy controls (controls). Participants will * take a urine and vaginal sample at the hospital. * answer a questionnaire regarding acceptability and preferences of self-sampling methods. * answer a lifestyle questionnaire.
• Women ≥ 60 years
• Diagnosed with cancer corpus uteri
• Living in Central Denmark Region or Southern Denmark Region, Denmark
• Able to provide written consent for participation
• Able to read and understand Danish
• Postmenopausal women ≥ 60 years
• Living in Central Denmark Region, Denmark
• Able to provide written consent for participation
• Able to read and understand Danish