Enlarged Prostate (BPH) Clinical Trials

Experimental: Arm A - Water Vapor Thermal Therapy (Rezum) group

procedures will be performed with only sedation or under general anathesia according to the patient preference and anathesiologist recommendations in a lithotomy position.~A single-use transurethral delivery device with an 18-gauge retractable needle is used to inject steam into the targeted area.~The procedure is visualized using an integrated cystoscope with a standard 4 mm 30° lens.~Saline irrigation is used to improve visualization and to cool down the urethral surface during the procedure.~Injection starts 1 cm distal to the bladder neck at 3 and 9 o'clock positions. Each injection deploys 0.5 ml of steam over 9 s at 103 °C raising the tissue temperature to 70 °C and it is recommended to wait for a couple of seconds postinjection to avoid loss of vapor through the puncture site.~After each injection, the needle is retracted and reinserted 1 cm distal to the previous injection until the proximal edge of the verumontanum creating tissue ablation along the prostatic urethra.

Active_comparator: Arm B - Prostatic Artery Embolization (PAE)

Patients will undergo the procedure under local anathesia. The Patients will lie in supine position and sterilization of the groin will be done then puncture of the right femoral and/or left femoral artery will be done using puncture set after local anathesia.~6F vascular sheath, then a 5F cobra head catheter will be introduced in right and/or left femoral artery to catheterize one of the internal iliac artery then catheterizing its anterior division.~An ipsilateral oblique view (30-40 degrees) and/or cranio-caudal view (10 degrees) will be obtained for differentiation of prostatic artery from other branches of anterior division \& for identification of prostatic artery origin.~Selective catheterization of prostatic artery with suitable type of micro catheter and adjusted microwire angle.~Embolizing material (400-500 micron microspheres) will be injected slowly and cautiously to avoid reflux under fluoroscopy guidance.