Accurate Diagnosis of Diabetes for Appropriate Management
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
The study has two aims: 1. To (1a) determine the frequency of monogenic diabetes misdiagnosed as type 1 diabetes (T1D) and (2) to define an algorithm for case selection. 2. To discover novel genes whose mutations cause monogenic diabetes misdiagnosed as T1D.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 1 day
Maximum Age: 25
Healthy Volunteers: t
View:
• Diagnosis of diabetes under the age of 25 as either type 1 or undetermined type.
Locations
Other Locations
Canada
The Montreal Children's Hospital
RECRUITING
Montreal
Contact Information
Primary
Constantin Polychronakos, MD
constantin.polychronakos@mcgill.ca
5144124400
Backup
Angeliki Makri, MD
angeliki.makri@mcgill.ca
5144124400
Time Frame
Start Date: 2019-09-24
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 5000
Treatments
Antibody-negative
Patient has been found negative for at least three T1D antibodies.~The investigators will proceed with whole exome sequencing
Antibody-positive
Patient has been found to be positive for at least one T1D autoantibody.~No further studies will be performed as part of the main study.
Related Therapeutic Areas
Sponsors
Leads: McGill University Health Centre/Research Institute of the McGill University Health Centre