EREctile Function Preservation for Prostate Cancer Radiation Therapy (ERECT); a Prospective Phase II Trial
Single-arm phase II trial of 70 men with low- or intermediate-risk prostate cancer receiving magnetic resonance guided adaptive radiotherapy (MRgRT) in 5 fractions of 7.25 Gy, additionally sparing the neurovascular bundles, the internal pudendal arteries, the corpora cavernosa, and the penile bulb for erectile function preservation.
• Age ≥18 years
• Histologically proven adenocarcinoma of the prostate
• Low-risk or intermediate-risk prostate cancer according to NCCN risk categories (low risk: T1c-T2a, Gleason score ≤6, and PSA \<10 µg/L; intermediate risk: T2b-T2c or Gleason score 7 or PSA 10-20 µg/L)
• Patients with pT1a/b tumor diagnosis after transurethral resection of the prostate (TURP)
• Domain score of 17-25 on the International Index of Erectile Function-5 (IIEF-5) questionnaire
• Karnofsky score of 70-100
• Written informed consent