Esophageal Cancer Overview
Learn About Esophageal Cancer
Esophageal cancer is cancer that starts in the esophagus. This is the tube through which food moves from the mouth to the stomach.
Cancer - esophagus
Esophageal cancer is not common in the United States. It occurs most often in men over age 50 years.
There are two main types of esophageal cancer, squamous cell carcinoma and adenocarcinoma. These two types look different from each other under the microscope.
Squamous cell esophageal cancer is linked to smoking and drinking too much alcohol.
Adenocarcinoma is the more common type of esophageal cancer. Having Barrett esophagus increases the risk for this type of cancer. Acid reflux disease (gastroesophageal reflux disease, or GERD) can develop into Barrett esophagus. Other risk factors include smoking, being male, or being obese.
Symptoms may include any of the following:
- Backward movement of food through the esophagus and possibly mouth (regurgitation)
- Chest pain not related to eating
- Difficulty swallowing solids or liquids
- Heartburn
- Vomiting blood
- Weight loss
EGD will be used to obtain a tissue sample from the esophagus to diagnose cancer.
When the cancer is only in the esophagus and has not spread, surgery may be done. The cancer and part, or all, of the esophagus is removed. The surgery may be done using:
- Open surgery, during which 1 or 2 larger incisions are made.
- Minimally invasive surgery, during which 2 to 4 small incisions are made in the belly. A laparoscope with a tiny camera is inserted into the belly through one of the incisions.
Radiation therapy may also be used instead of surgery in some cases when the cancer has not spread outside the esophagus.
Either chemotherapy, radiation, or both may be used to shrink the tumor and make surgery easier to perform.
If the person is too ill to have major surgery or the cancer has spread to other organs, chemotherapy or radiation may be used to help reduce symptoms. This is called palliative therapy. In such cases, the disease is usually not curable.
Besides a change in diet, other treatments that may be used to help the patient swallow include:
- Dilating (widening) the esophagus using an endoscope. Sometimes a stent is placed to keep the esophagus open.
- A feeding tube into the stomach.
- Photodynamic therapy, in which a special drug is injected into the tumor and is then exposed to light. The light activates the medicine that attacks the tumor.
MD Anderson
Wayne Hofstetter is a Thoracic Surgeon in League City, Texas. Dr. Hofstetter is rated as an Elite provider by MediFind in the treatment of Esophageal Cancer. His top areas of expertise are Esophageal Cancer, Lung Cancer, Non-Small Cell Lung Cancer (NSCLC), Endoscopy, and Hepato-Pancreato-Biliary Surgery.
H Lee Moffitt Cancer Ctr And Res Inst Life Time Cancer Scrn Ctr Inc
Sarah Hoffe is a Radiation Oncologist in Tampa, Florida. Dr. Hoffe is rated as an Elite provider by MediFind in the treatment of Esophageal Cancer. Her top areas of expertise are Pancreatic Cancer, Anal Cancer, Esophageal Cancer, Lymphadenectomy, and Liver Embolization. Dr. Hoffe is currently accepting new patients.
MD Anderson
Zhongxing Liao is a Radiation Oncologist in Houston, Texas. Dr. Liao is rated as an Elite provider by MediFind in the treatment of Esophageal Cancer. Her top areas of expertise are Lung Cancer, Non-Small Cell Lung Cancer (NSCLC), Esophageal Cancer, and Small Cell Lung Cancer (SCLC).
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone
When the cancer has not spread outside the esophagus, surgery may improve the chance of survival.
When the cancer has spread to other areas of the body, a cure is generally not possible. Treatment is directed toward relieving symptoms.
Complications may include:
- Pneumonia
- Severe weight loss from not eating enough
Contact your health care provider if you have difficulty swallowing with no known cause and it does not get better. Also contact your provider if you have other symptoms of esophageal cancer.
To reduce your risk of cancer of the esophagus:
- Do not smoke.
- Limit or do not drink alcoholic beverages.
- Get checked by your doctor if you have severe GERD.
- Get regular checkups if you have Barrett esophagus.
Summary: The goal of this study is to evaluate the safety and effectiveness of EVOLVE104 in participants with advanced urothelial and squamous cell carcinomas who have previously taken standard treatment options, have declined or have been ineligible for treatment with these medications. Participants with advanced or metastatic cancer who meet all eligibility criteria may be eligible to participate in the ...
Summary: This trial collects multiple tissue and blood samples, along with medical information, from cancer patients. The Cancer Moonshot Biobank is a longitudinal study. This means it collects and stores samples and information over time, throughout the course of a patient's cancer treatment. By looking at samples and information collected from the same people over time, researchers hope to better underst...
Published Date: August 07, 2023
Published By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Ajani JA, D'Amico TA, Bentrem DJ. Esophageal and esophagogastric junction cancers, version 2.2023, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2023;21(4): 393-422. PMID: 37015332 pubmed.ncbi.nlm.nih.gov/37015332/.
Ku GY, Ilson DH. Cancer of the esophagus. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 71.
National Cancer Institute website. Esophageal cancer treatment (PDQ) - health professional version. www.cancer.gov/types/esophageal/hp/esophageal-treatment-pdq. Updated May 11, 2023. Accessed August 9, 2023.