• Histologic diagnosis of local advance squamous cell thoracic esophageal carcinoma of Stage (T1N1-3 or T2-3N0-3 M0), (8th Union for International Cancer Control, UICC-TNM).

• No metastatic lymph node in cervical by color doppler sonography.

• Patients must not have received any prior anticancer therapy of esophageal carcinoma.

• Age ranges from 18 to 75 years.

• Without operative contraindication.

• Absolute white blood cells count ≥4.0×109/L, neutrophil ≥1.5×109/L, platelets ≥100.0×109/L, hemoglobin ≥90g/L, and normal functions of liver and kidney, total bilirubin（TBIL）≤1.5N, aspartate aminotransferase (AST)≤2.5N, alanine aminotransferase(ALT)≤2.5N, prothrombin time(PT)≤1.5N, and activated partial thromboplastin time(APTT) is in normal range, endogenous creatinine clearance rate(CRE)≤1.5N.

• Patients must not have diagnosed with other cancer and must not received any prior anticancer therapy except prostatic cancer with more than 5 years disease-free survival(DFS).

• expected R0 resection.

• ECOG 0～1.

⁃ Patients should agree to use contraceptive measures during the study period and within 6 months of the end of the study. Women must be non-lactation.

⁃ Signed informed consent document on file. 10. .