Administration of Oral Prednisolone to Prevent Esophageal Stricture After Balloon-type Radiofrequency Ablation for Long-segment Esophageal Neoplasia
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
Endoscopic radiofrequency ablation (RFA) has shown good efficacy and safety in eradicating flat-type early esophageal squamous cell neoplasia (ESCN). However, post-RFA stricture is still a major concern, especially when treating long-segment early ESCNs. The aim of this study was to investigate the efficacy and safety of oral prednisolone to prevent post-RFA stricture.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 80
Healthy Volunteers: f
View:
• Histology from endoscopic biopsies showed squamous intraepithelial neoplasia without stromal invasion;
• No lymph node metastasis on endoscopic ultrasound or computed tomography;
• Magnifying endoscopy showed the intraepithelial papillary capillary loop as type B1 pattern, according to the classification of the microvascular architecture of superficial esophageal carcinoma.
Locations
Other Locations
Taiwan
EDA Hospital
RECRUITING
Kaohsiung City
Contact Information
Primary
Wen-Lun Wang, Ph.D
warrengodr@gmail.com
+886918464373
Time Frame
Start Date: 2016-01-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 50
Treatments
Experimental: Administration of oral prednisolone
Oral prednisolone start at a dose of 30 mg/day on the third day after RFA, and continue for 4 weeks.
Related Therapeutic Areas
Sponsors
Leads: E-DA Hospital