Predicting Esophageal Cancer Borders Using PET-Imaging PEGASUS
Status: Recruiting
Location: See location...
Intervention Type: Drug, Procedure, Radiation
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The study examines the diagnostic precision of endosonography, mpMRI and PET/CT in defining tumor boundaries and tumor spread before and after neoadjuvant therapy and definitive surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Histologically confirmed adenocarcinoma or squamous cell carcinoma of the esophagus, including AEG I and AEG II tumors in the primary situation
• Planned surgical treatment of esophageal carcinoma
• Possible staging advantage through FAPI PET/CT diagnostics
• Patient information and written consent
⁃ \> KI 60% or ECOG 0/1 (at least: self-sufficiency)
• Age ≥ 18 years
Locations
Other Locations
Germany
Department of Radiotherapy, University of Heidelberg
RECRUITING
Heidelberg
Contact Information
Primary
Christoph Fink, MD
christoph.find.@med.uni-heidelberg.de
+496221 56
Time Frame
Start Date: 2024-03-01
Estimated Completion Date: 2026-04
Participants
Target number of participants: 30
Treatments
Other: Group 1, Surgery
cT1-2 N0, all histologies: primary surgical therapy
Other: Group 2, Chemotherapy and surgery
cT3-4 and/or N+, adenocarcinomas: neoadjuvant chemotherapy, surgical therapy
Other: Group 3, chemotherapy, radiotherapy and surgery
cT3-4 and/or N+, squamous cell carcinomas: neoadjuvant radio(chemo)therapy, surgical therapy
Related Therapeutic Areas
Sponsors
Leads: University Hospital Heidelberg