Predicting Postoperative Chemotherapy Efficacy in Patients With Esophageal Squamous Cell Carcinoma by Biopsy Specimens.
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY
Esophageal cancer remains a disease with a poor prognosis. Chemotherapy is an important part of its treatment, but there are cases in which chemotherapy is ineffective. The investigators aim to develop a model to predict the response to chemotherapy by DNA methylation of preoperative biopsy specimens to identify the chemotherapy ineffective group.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Healthy Volunteers: f
View:
• Patients who had histologically confirmed esophageal squamous cell carcinoma.
• Patients who had undergone chemotherapy.
• Patients receiving initial chemotherapy
• Written informed consent following full study information is provided to the patient.
Locations
Other Locations
Japan
Yamanashi Universiy
RECRUITING
Chūō
Contact Information
Primary
Ajay Goel, PhD
AJGOEL@COH.ORG
6262183452
Backup
Koichi Takiguchi, PhD
ktakiguchi@coh.org
6262183452
Time Frame
Start Date: 2004-06-01
Estimated Completion Date: 2026-06-18
Participants
Target number of participants: 150
Treatments
Chemotherapy response patients.
Responders according to the response evaluation criteria in solid tumors (RECIST).~A panel of DNA methylation, whose specific methylation level is tested DNA from resection tissue with Methylation-specific PCR(MSP)
Chemotherapy non-response patients
Responders according to the response evaluation criteria in solid tumors (RECIST).~A panel of DNA methylation, whose specific methylation level is tested DNA from resection tissue with Methylation-specific PCR(MSP)
Related Therapeutic Areas
Sponsors
Leads: City of Hope Medical Center