
Overview
Fyza Shaikh is an Assistant Professor in Cancer Immunology in the Department of Oncology in the Sidney Kimmel Comprehensive Cancer Center. She joined the faculty after completing her fellowship in medical oncology at Johns Hopkins School of Medicine (JHSOM) and residency in internal medicine at the University of Pittsburgh Medical Center as part of the ABIM research pathway. She received her MD and PhD in Microbiology and Immunology at Vanderbilt University School of Medicine. The Shaikh lab at JHSOM is focused on how the microbiome impacts host immunological responses to tumorigenesis and anti-tumor responses to immunomodulatory agents. The lab uses a combination of translational approaches using samples collected from human cohort studies and clinical trials as well as murine models to ask more detailed mechanistic questions and works across multiple tumor types (melanoma, lung, esophageal, head and neck, etc). The overall approach uses combination of clinical, computational, and lab-based techniques using a rich biorepository containing clinically annotated metadata with known and putative biomarkers of ICI response, such as PD-L1 and tumor mutational burden, paired with longitudinal fecal and plasma samples that correlate with clinical milestones (i.e. response/nonresponse by imaging and treatment-related toxicity). The goal is to focus on microbial functionality and build defined bacterial consortia that can then be tested in murine models to define colonization, metabolomics, and intra-tumoral immune response. This translational approach, with cross-sectional and longitudinal analysis of human samples, paired with mechanistic studies in murine models, has the potential to address both limitations in previously published studies and generate new hypotheses to make advances in this field and improve ICI responses for patients with advanced malignancies.
Dr. Shaikh is rated as an Experienced provider by MediFind in the treatment of Esophageal Cancer. Her top areas of expertise are Lung Cancer, Non-Small Cell Lung Cancer (NSCLC), Melanoma, and Esophageal Cancer.
Her clinical research consists of co-authoring 17 peer reviewed articles. MediFind looks at clinical research from the past 15 years. In particular, she has co-authored 1 article in the study of Esophageal Cancer.
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- INDEMNITY
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- PPO
- HMO
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Locations
Baltimore, MD 21287
Clinical Research
Clinical research consists of overseeing clinical studies of patients undergoing new treatments and therapies, and publishing articles in peer reviewed medical journals. Providers who actively participate in clinical research are generally at the forefront of the fields and aware of the most up-to-date advances in treatments for their patients.
Johns Hopkins Bayview Medical Center
Josephine (Joy) Feliciano, M.D., is an assistant professor of oncology at The Johns Hopkins University School of Medicine and a faculty member of the Johns Hopkins Kimmel Cancer Center. She serves as medical director of the Thoracic Oncology Program at Johns Hopkins Bayview Medical Center, as well as co-director of the outpatient oncology clinic at Johns Hopkins Bayview. Dr. Feliciano completed both undergraduate and postgraduate medical training at Georgetown University, as well as residency training, where she was selected as chief resident. She spent three years at Northwestern completing clinical training in hematology and oncology, then joined the faculty at University of Maryland Greenberg Cancer Center. At the University of Maryland, Feliciano focused on lung cancer screening and health disparities research for patients with lung cancer. While there, she also earned a certificate degree in the Epidemiology and Human Genetics Program for Clinical Investigation. Dr. Feliciano is also a member of the Miller Coulson Academy of Clinical Excellence. She also serves as the inaugural Medical Director of the Sidney Kimmel Cancer Diagnostic and Treatment Planning Center. Dr. Feliciano is rated as an Elite provider by MediFind in the treatment of Esophageal Cancer. Her top areas of expertise are Non-Small Cell Lung Cancer (NSCLC), Lung Cancer, Small Cell Lung Cancer (SCLC), and Gastroesophageal Junction Cancer.
Adrian Murphy is an Oncologist in Baltimore, Maryland. Dr. Murphy is rated as an Advanced provider by MediFind in the treatment of Esophageal Cancer. His top areas of expertise are Cholangiocarcinoma (Bile Duct Cancer), Familial Colorectal Cancer, Colorectal Cancer, Pancreaticoduodenectomy, and Penectomy.
The Johns Hopkins Hospital
Dr. Anagnostou is an Associate Professor of Oncology, co-director of the Upper Aerodigestive Malignancies Program, director of the Thoracic Oncology Biorepository, leader of Precision Oncology Analytics and co-leader of the Molecular Tumor Board and the Thoracic Oncology Precision Medicine Center of Excellence in the Sidney Kimmel Cancer Center at Johns Hopkins. She has established the Molecular Oncology laboratory that seeks to understand the genomic wiring of response and resistance to immunotherapy through integrative genomic, transcriptomic, single-cell and liquid biopsy analyses of tumor and immune evolution. Dr. Anagnostou graduated from Medical School of the National and Kapodistrian University of Athens, Greece and received a PhD from the same institution. After completing her internal medicine residency at Yale-New Haven Hospital, she subsequently trained in Medical Oncology at Johns Hopkins. Dr. Anagnostou is a translational cancer investigator, focusing on large-scale genomic and liquid biopsy analyses in human cancers. Her group has discovered novel genomic mechanisms of response and resistance to immunotherapy and her research is particularly focused on understanding the molecular mechanisms of response and resistance to these therapies, capturing these by minimally invasive methods and translating this knowledge into novel technologies and innovative therapeutic approaches for cancer patients. She is the international study chair of the first ctDNA-based molecular response adaptive immuno-chemotherapy clinical trial for metastatic non-small cell lung cancer (NCT04093167). Dr. Anagnostou's long term goal is to transform medical oncology to personalized molecular oncology, where treatment decisions are tailored to cancer genomics and molecular real-time response assessments informed by liquid biopsies. Dr. Anagnostou is rated as an Advanced provider by MediFind in the treatment of Esophageal Cancer. Her top areas of expertise are Non-Small Cell Lung Cancer (NSCLC), Lung Cancer, Mesothelioma, and Gastroesophageal Junction Cancer.
Areas of Expertise
MediFind evaluates expertise by pulling from factors such as number of articles a doctor has published in medical journals, participation in clinical trials, speaking at industry conferences, prescribing and referral patterns, and strength of connections with other experts in their field.
Learn more about MediFind’s expert tiers
- Experienced
- Esophageal CancerDr. Shaikh isExperienced. Learn about Esophageal Cancer.
- Gallbladder AdenocarcinomaDr. Shaikh isExperienced. Learn about Gallbladder Adenocarcinoma.
- Gallbladder CancerDr. Shaikh isExperienced. Learn about Gallbladder Cancer.
- Lung CancerDr. Shaikh isExperienced. Learn about Lung Cancer.
- MelanomaDr. Shaikh isExperienced. Learn about Melanoma.
- Non-Small Cell Lung Cancer (NSCLC)Dr. Shaikh isExperienced. Learn about Non-Small Cell Lung Cancer (NSCLC).

