The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding: Prospective Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Determine the effect of high-dose pancreatic enzyme supplementation on nutritional indicators and clinical course in critically ill patients undergoing enteral nutrition.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adults 19 years and older
• Hospitalized in the surgical/medical intensive care unit of the Seoul National University Hospital
• Enteral nutrition
• Patients who consented to this study
• Patients with risk factors for pancreatic exocrine dysfunction
‣ Shock (Norepinephrine)
⁃ Sepsis (3 rd definition of sepsis)
⁃ Diabetes
⁃ Cardiac arrest
⁃ hyperlactatemia serum lactate \> 2 mmol/L)
⁃ Mechanical ventilation
⁃ Continuous renal replacement therapy
Locations
Other Locations
Republic of Korea
Seoul National University Hospital
RECRUITING
Seoul
Contact Information
Primary
Oh
faun1226@gmail.com
+82-2-2072-3538
Time Frame
Start Date: 2021-07-07
Estimated Completion Date: 2026-07-31
Participants
Target number of participants: 170
Treatments
Experimental: Intervention
Exocrine Pacancreatic enzyme(Norzyme Capsule 40000 capsules) after meals 3 times a day
Placebo_comparator: Control
Placebo after meals 3 times a day
Related Therapeutic Areas
Sponsors
Leads: Seoul National University Hospital