Amino Acid Supplementation and Physical Exercise in Facioscapulohumeral Muscular Dystrophy: Effects on Body Composition and Physical Efficiency in a Model of Muscular Disease
This study evaluates whether amino acid supplementation, combined with a structured diet and exercise program, improves body composition (increased muscle mass and reduced fat mass) and physical performance in individuals with facioscapulohumeral muscular dystrophy (FSHD). The study also compares responses to the intervention between individuals with FSHD and healthy individuals matched for age and sex.
• Subjects of both sexes with a diagnosis of FSHD, confirmed by genetic testing.
• Age between 18 and 50 years.
• Belonging to clinical category A among the four defined in the Comprehensive Clinical Evaluation Form. These patients present the most characteristic signs of the disease: muscle weakness of the facial and scapular girdle.
• Clinical score ranging from 2 to 5.
• Preserved ability to walk at the time of enrollment.
• Absence of central or peripheral nervous system involvement based on neurological history and physical examination.
• Absence of scoliosis, limb contractures, and tendon retractions.