Understanding the Role of Right Atrial Ectopy-triggering Ganglionated Plexuses in Atrial Fibrillation

Status: Recruiting
Location: See location...
Intervention Type: Other, Diagnostic test, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Atrial fibrillation (AF) is the most common rhythm disturbance of the heart. It can affect people of any age but usually happens as we get older. It can cause palpitations, breathlessness, lethargy, and fainting attacks. It is also associated with an increased risk of strokes. The best treatment for it at the moment involves burning or freezing (ablation) the heart muscle in a part of the heart called the left atrium. The ablation injures the heart muscle around the so-called pulmonary veins and the procedure is called a 'pulmonary vein isolation'. This procedure work in about 60% of people. The study team have found that there are nerve endings in the heart that also cause AF and have shown that ablating these nerve endings also prevents AF. These Nerve endings are known as ganglionated plexuses (GPs). The study team would now like to perform a trial in people who still have AF after the usual pulmonary vein procedure. The study team hope that ablating the nerve endings that cause AF (GPs), we will stop their AF coming back. The study team will compare this procedure to the normal approach of doing the pulmonary vein isolation again

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• Males or females from 18 to 85yrs old

• Symptomatic paroxysmal atrial fibrillation

• Suitable candidate for catheter ablation

• Signed informed consent

Locations
Other Locations
United Kingdom
Hammersmith Hospital
RECRUITING
London
Contact Information
Primary
Jamie Kay, MBBS BMedSci
jamie.kay@imperial.ac.uk
02033131000
Time Frame
Start Date: 2023-02-21
Estimated Completion Date: 2027-12-02
Participants
Target number of participants: 116
Treatments
Experimental: Intervention
Right atrial GP ablation in addition to pulmonary vein isolation
Active_comparator: Control
PVI alone with no GP mapping or ablation
Related Therapeutic Areas
Sponsors
Leads: Imperial College London

This content was sourced from clinicaltrials.gov