Experimental: Active group

The transcranial magnetic stimulation sessions were carried out using the MAGSTIM TMS equipment (Company Limited, Whitland, wales, UK). The investigators used the figure of eight or butterfly coil. The experimental group received real rTMS as follow: The intensity of the stimulus employed in treatment has used the motor threshold (MT) as the basic measure. The MT is used as a measurement index because the motor cortex is the only brain region which gives an easily detected signal \[muscle twitch\] when depolarized.The main stimulation parameters were 24 trains at120% of motor threshold for 60 seconds at 1 Hz and a 45-second interval between trains. The investigators subsequently provided a total of 1,200 pulses at each of the 20 sessions. The stimulation area was the right dorsolateral prefrontal area that was defined as the region 5 cm rostral in the same sagittal plane as the optimal site for MT production in the first dorsal interosseous

Sham_comparator: control group

The control group received sham rTMS as in the experimental group; however, sham current was with the coil placed perpendicular to the with the coil placed perpendicular to the scalp. The investigator responsible for delivering rTMS had no contact with the patients, ensuring a double-blind procedure.