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Study Evaluating the Impact of Using Triplex Rapid Diagnostic Tests (SARS-CoV-2/Influenza/RSV) on Antibiotic Prescribing in the General Population in Community Settings

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Respiratory infections are very common, especially during winter, and are often caused by viruses such as influenza, SARS-CoV-2 or respiratory syncytial virus (RSV). These illnesses are generally mild, but their symptoms do not always allow a clear distinction to be made between a viral infection and a bacterial infection. In the absence of a precise diagnosis, antibiotics may be prescribed when they are not necessary in many cases. However, the excessive use of antibiotics contributes to the development of bacterial resistance, which is a major public health issue. The aim of this study is to better understand whether the use of a rapid test (called TROD), which can quickly identify certain respiratory viruses, can help doctors reduce unnecessary antibiotic prescriptions for these infections. The test will be performed using a swab gently inserted into the nose.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Healthy Volunteers: f
View:

• Age ≥ 1 year

• Presenting with:

‣ Either fever (temperature \> 38°C measured by patient or physician) within the past 72 hours, and one of the following symptom combinations:

• Rhinorrhea (white, yellow, or green discharge) and/or nasal obstruction, and cough

∙ Body aches, cough, and fatigue

∙ Odynophagia and negative strepto-test

∙ Cough

∙ Otalgia

⁃ Or suspicion of lower respiratory tract infection: signs of infection (respiratory rate \> 20/min, heart rate \> 100/min, fatigue, Body aches, chills, or fever), associated with pulmonary localization signs \[cough, sputum, chest pain, auscultatory abnormality (rhonchi, crackles, or wheezing)\]

• Affiliation with the national health insurance system

• Informed consent obtained from the adult participant, or from the person(s) with parental authority for a minor participant

Locations
Other Locations
France
Assistance Publique - Hôpitaux de Paris
RECRUITING
Garches
Contact Information
Primary
Aurélien DINH, MD, PhD
aurelien.dinh@aphp.fr
+33 1 47 10 77 60
Backup
Jacques ROPERS, PharmD
jacques.ropers@aphp.fr
+33 1 42 16 03 48
Time Frame
Start Date: 2026-01-07
Estimated Completion Date: 2026-04
Participants
Target number of participants: 2000
Treatments
No_intervention: Control
Patients without triplex TROD tests. Doctors may or may not prescribe antibiotics probabilistically as usual.
Experimental: TROD
Patient with triplex TROD test. Doctors may or may not prescribe antibiotics with the help of the results of triplex TROD tests.
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov