Follicular Lymphoma Clinical Trials

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An Exploratory Study to Correlate the Level of Cell-free DNA With Response to First-line Treatment in Patients With Follicular Lymphoma

Who is this study for? Patients with follicular lymphoma
What treatments are being studied? cfDNA testing
Status: Recruiting
Location: See all (7) locations...
Intervention Type: Diagnostic test, Other
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

The researchers are doing this study to measure and test cell-free DNA (cfDNA) in the blood before, during, and after first-line treatment for follicular lymphoma. They will look at whether cfDNA levels are related to a person's response to the usual first-line treatment for follicular lymphoma. Researchers also want to understand how different genetic changes in follicular lymphoma relate to a person's response to the usual first-line treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• ≥18 years of age at time of signing informed consent. Consent is permitted from either the participant or from a Legally Authorized Representative (LAR) on their behalf.

• Histology-confirmed follicular lymphoma grade 1-3a, verified by the enrolling institution

• Ability to adhere to the study visit schedule and all the protocol requirements

• Measurable FDG-avid disease

• Not applicable for retrospective patients in CR

Locations
United States
New Jersey
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
RECRUITING
Basking Ridge
Memorial Sloan Kettering Monmouth (All protocol activities)
RECRUITING
Middletown
Memorial Sloan Kettering Bergen (All protocol Activities)
RECRUITING
Montvale
New York
Memorial Sloan Kettering Commack (All Protocol Activities)
RECRUITING
Commack
Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITING
Harrison
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING
New York
Memorial Sloan Kettering Nassau (All Protocol Activities)
RECRUITING
Uniondale
Contact Information
Primary
Paola Ghione, MD
ghionep@mskcc.org
646-608-4263
Backup
Maria Arcila, MD
212-639-7879
Time Frame
Start Date: 2020-07-08
Estimated Completion Date: 2026-07
Participants
Target number of participants: 100
Treatments
Experimental: Prospective Group
Study participants with untreated, newly diagnosed follicular lymphoma will have blood collected for cfDNA testing before, during, and after their first-line treatment or observation period
Experimental: Retrospective Group
Study participants who have received first-line treatment for follicular lymphoma and are in complete remission will have blood collected for cfDNA testing. In the retrospective cohort, MSKCC patients with CRs lasting ≥10 years after induction therapy will be studied. Initial tumor tissue (if available) will be collected to examine the status of s cfDNA in patients with long-term remissions. Blood samples will be collected once, if the patient has interesting results (e.g. positive cfDNA sample despite CR on imaging, etc.) then additional blood samples may be taken during follow up visits.
Sponsors
Leads: Memorial Sloan Kettering Cancer Center

This content was sourced from clinicaltrials.gov