The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study
To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer traumatic spinal fracture and/or dislocation of the spinal column but without neurologic injury will be enrolled as non-SCI spine trauma control participants.
• Age ≥ 19 years
• Blunt (non-penetrating) traumatic SCI
• Baseline neurologic impairment deemed complete (AIS grade A) or incomplete (AIS grade B, C, or D) based on clinical history/examination and/or diagnostic imaging
• Bony spinal level involvement between C0 and L1, inclusive
• Ability to have initial blood sample drawn within 24 hours of injury
• Treated either surgically or non-surgically
• Ability to provide informed consent according to the IRB/EC defined and approved procedures
• Age ≥ 19 years
• Traumatic spinal fracture and/or dislocation between C0 and L1 (inclusive) without SCI
• Treated either surgically or nonsurgically
• Ability to have initial blood sample drawn within 24 hours of injury
• Ability to provide informed consent according to the IRB/EC defined and approved procedures