Frontotemporal Dementia Clinical Trials

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The Comprehensive Assessment of Neurodegeneration and Dementia Study

Status: Recruiting
Location: See all (19) locations...
Study Type: Observational
SUMMARY

This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits. Participants are/will be recruited at sites across Canada and will undergo assessments, neuroimaging, and biological sample collection.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 90
Healthy Volunteers: t
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• Has subjective or objective cognitive impairment

• Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member)

• Sufficient proficiency in English or French to undertake self report and neuropsychological testing

• Geographic accessibility to the study site

• Must have a study partner who can participate as required in the protocol (provide corroborative information)

• Up to 12 years of education

• Fits into one of the following groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment

Locations
Other Locations
Canada
University of Calgary
RECRUITING
Calgary
University of Alberta Hospital
RECRUITING
Edmonton
Veteran's Memorial Building
RECRUITING
Halifax
Hamilton General Hospital
RECRUITING
Hamilton
Gait and Brain Lab
RECRUITING
London
St. Joseph's Health Care London
RECRUITING
London
Clinique de cognition Institut universitaire de gériatrie de Montréal
RECRUITING
Montreal
Jewish General Hospital/McGill Memory Clinic
RECRUITING
Montreal
Research Institute of the McGill University Health Centre
ACTIVE_NOT_RECRUITING
Montreal
Bruyère Research Institute
ACTIVE_NOT_RECRUITING
Ottawa
Kawartha Centre
ACTIVE_NOT_RECRUITING
Peterborough
Hôpital Enfant-Jésus
RECRUITING
Québec
Centre de recherche sur le vieillissement CIUSSS de l'Estrie-CHUS
ACTIVE_NOT_RECRUITING
Sherbrooke
Baycrest Clinical Unit
RECRUITING
Toronto
Sunnybrook Health Sciences Centre
ACTIVE_NOT_RECRUITING
Toronto
University Health Network Memory Clinic
ACTIVE_NOT_RECRUITING
Toronto
Djavad Mowafaghian Centre for Brain Health
RECRUITING
Vancouver
Island Health
NOT_YET_RECRUITING
Victoria
University of Waterloo
ACTIVE_NOT_RECRUITING
Waterloo
Contact Information
Primary
Howard Chertkow, MD
howard.chertkow@mcgill.ca
514 340 8222
Backup
Randi Pilon
Randi.Pilon@ladydavis.ca
514 8339709
Time Frame
Start Date: 2016-06
Estimated Completion Date: 2029-12
Participants
Target number of participants: 1573
Treatments
Normal healthy elderly
participants with no subjective or objective cognitive deficits or decline.
Subjective Cognitive Decline
Participants with a complaint of subjective cognitive impairment, but no objective evidence of such.
Mild Cognitive Impairment (MCI)
Participants with objective evidence of cognitive impairment, but it does not impact on daily function.
Vascular MCI
Participants meeting criteria of MCI who also show signs of cerebrovascular disease on imaging but have no history of stroke.
Alzheimer's Disease
Participants with dementia of the Alzheimer's type according to the National Institute of Aging-Alzheimer's Association criteria
Dementia of Mixed Etiology
Participants with dementia and evidence of more than one etiology.
Lewy Body/Parkinson's spectrum
Participants with Parkinson's disease who show mild or moderate cognitive impairment and/or dementia.
Frontotemporal dementia (FTD) spectrum
Participants with behavioral variant FTD, primary progressive aphasia, progressive supranuclear palsy, or corticobasal syndrome
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR), Nova Scotia Health Research Foundation, Eli Lilly and Company, Pfizer, Michael Smith Foundation for Health Research, Saskatchewan Health Research Foundation, Sanofi, New Brunswick Health Research Foundation, Alzheimer Society of Canada, Ontario Brain Institute, Canadian Consortium on Neurodegeneration in Aging, Canadian Nurses Foundation (CNF)
Leads: McGill University

This content was sourced from clinicaltrials.gov