Comparison of Outcomes Between Femtosecond Laser-Assisted and Conventional Phacoemulsification in Fuchs Endothelial Corneal Dystrophy Patients With Cataracts

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational study is to compare the mid- to long-term efficacy of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) in patients with moderate to severe Fuchs' endothelial corneal dystrophy (FECD) complicated by cataracts. The main questions it aims to answer are: Does FLACS lead to better preservation of corneal endothelial cells compared to CPS in patients with moderate to severe FECD? How do visual outcomes and corneal transparency compare between FLACS and CPS in this patient population? Comparison Group: Researchers will compare patients undergoing FLACS with those undergoing CPS to evaluate differences in endothelial cell loss, corneal thickness, visual acuity, and corneal transparency. Participants: Adults aged 40 years and older diagnosed with moderate to severe FECD (endothelial cell density \<1500 cells/mm²). Patients scheduled for cataract surgery at participating centers. Participants will undergo: Preoperative evaluations, including visual acuity tests, corneal endothelial cell density assessment (central and five peripheral zones), corneal thickness, and corneal densitometry. Surgical intervention with either FLACS or CPS. Postoperative follow-ups at 1 day, 3 days, 1 week, 1 month, 3 months, 6 months, 1 year, and 2 years, including assessments of endothelial cell density, visual acuity, and corneal thickness. This study aims to provide evidence-based recommendations for optimizing surgical strategies in high-risk patients with FECD and cataracts.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Healthy Volunteers: f
View:

• Patients scheduled for cataract surgery

• Age ≥40 years

• Diagnosed with moderate to severe FECD (endothelial cell density \<1500 cells/mm²)

Locations
Other Locations
China
Eye and ENT hospital of Fudan University
RECRUITING
Shanghai
Contact Information
Primary
Jin Yang
jin_er76@hotmail.com
+86 021-64377134
Time Frame
Start Date: 2025-01-01
Estimated Completion Date: 2030-01
Participants
Target number of participants: 120
Treatments
conventional phacoemulsification surgery (CPS)
femtosecond laser-assisted cataract surgery (FLACS)
Sponsors
Leads: Eye & ENT Hospital of Fudan University

This content was sourced from clinicaltrials.gov