• Chinese#

• Stable vital signs, ECOG:0-1;

• Patients have a diagnosis of resectable gallbladder carcinoma by histopathology or cytopathology after radical surgery.

• Adequate fresh tumor tissue for genome sequencing and immunohistochemistry test; harboring mutations or abnormal activation of erb-b2 receptor tyrosine kinase signal pathway components

• Life expectancy of more than 18 weeks;

• T stage≥ T2 or histopathological lymph node positive according to AJCC (8th edition) staging.

• Adequate hepatic, hematologic and renal functions(ALT≤5×upper limit of normal (ULN), AST≤5×ULN, the Child-Pugh classification for class A or B, white blood cells≥3×10\^9/L, neutrophils≥1.5×10\^9/L, platelets≥75×10\^9/L , hemoglobin ≥ 90g/L, creatinine clearance rate≥60ml/min;

• Volunteer for this study, have written informed consent and have good Patient compliance;

• Female patients of childbearing potential and their mates agree to avoid pregnancy.