Long Term Outcome of Easophageal Atresia : Transmics Profiles in Adolescence

Status: Recruiting
Location: See all (32) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Oesophageal atresia (OAEA), a malformation of the oesophagus present from birth, is characterized by the interruption of the continuity of the oesophagus, which then ends in a cul-de-sac. (Source: Fimatho) An operation is then required to restore continuity to the esophagus. Although this operation enables the vast majority of children to survive the neonatal period, health problems such as gastro-oesophageal reflux, eating difficulties, respiratory problems and growth problems persist throughout life. The aim of the project is to create a prospective cohort of adolescents aged 13/14, nested in the national AO registry. of adolescents born with esophageal atresia, including a biobank of esophageal mucosa and plasma blood samples. Once the clinical and omic data have been collected, the data will be transferred to the France Cohortes information system for analysis, in order to assess the long-term outcome of this rare disease and establish multi-omic profiles. Once the clinical data have been collected and the omics data (derived from analysis of the biobank's biological samples) have been generated, they will be analyzed by the project partners to assess the long-term outcome of OA and establish multiomic profiles. The raw data will be available on the France Cohorte platform.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 13
Maximum Age: 14
Healthy Volunteers: f
View:

• For the oesophageal atresia group :

• Born with oesophageal atresia (EA) in France or in French overseas departments and territories

• Anastomosis performed

• Included into the ReNaTo registry

• Aged 13 or 14 during the recruitment period

• Patient willing to comply with all study procedures and duration

• Patient will social security

⁃ For the blood sub-study :

• Upper GI endoscopy performed as part of care between 13 and 14 years of age with esophageal mucosal biopsy sampling

• Patient having given written consent to participate in the study

⁃ For the control arm:

• Upper GI endoscopy performed as part of care between 10 and 14 years of age with oesophageal mucosal biopsy sampling

• Upper GI endoscopy performed as part of care for chronic or acute digestive signs to rule out organic etiology (peptic esophagitis, gastric esophagitis, eosinophilic esophagitis or ulcer)

• Normal endoscopy and histology

• No chronic progressive disease

Locations
Other Locations
France
CHU Amiens
NOT_YET_RECRUITING
Amiens
CHU Angers
RECRUITING
Angers
CHU Besançon
NOT_YET_RECRUITING
Besançon
CHU Bordeaux
RECRUITING
Bordeaux
HLC Hôpital Mère Enfant
RECRUITING
Bron
CHU Caen
RECRUITING
Caen
CHU Clermont-Ferrand
NOT_YET_RECRUITING
Clermont-ferrand
CHI Créteil
RECRUITING
Créteil
CHU Dijon
RECRUITING
Dijon
CHU Grenoble
NOT_YET_RECRUITING
La Tronche
AP-HP Hôpital Kremlin Bicêtre
NOT_YET_RECRUITING
Le Kremlin-bicêtre
CHU Le Mans
NOT_YET_RECRUITING
Le Mans
CHU de Lille Hôpital Jeanne de Flandre
RECRUITING
Lille
CHU Limoges
NOT_YET_RECRUITING
Limoges
AP-HM Hôpital La Timone
RECRUITING
Marseille
CHU Montpellier
RECRUITING
Montpellier
CHU Nancy Hôpital Brabois
NOT_YET_RECRUITING
Nancy
CHU Nantes
RECRUITING
Nantes
CHU Nice
NOT_YET_RECRUITING
Nice
CHU Orléans
NOT_YET_RECRUITING
Orléans
AP-HP Hôpital Armand Trousseau
NOT_YET_RECRUITING
Paris
AP-HP Hôpital Necker
RECRUITING
Paris
AP-HP Hôpital Robert Debré
RECRUITING
Paris
CHU Poitiers
RECRUITING
Poitiers
CHU de Reims
NOT_YET_RECRUITING
Reims
CHU de Rennes
RECRUITING
Rennes
CHU Rouen
NOT_YET_RECRUITING
Rouen
CHU Saint Etienne
NOT_YET_RECRUITING
Saint-etienne
CHU Strasbourg
NOT_YET_RECRUITING
Strasbourg
CHU Toulouse
NOT_YET_RECRUITING
Toulouse
CHU Tours
NOT_YET_RECRUITING
Tours
Martinique
CHU Fort de France
RECRUITING
Fort-de-france
Time Frame
Start Date: 2023-11-14
Estimated Completion Date: 2026-11-14
Participants
Target number of participants: 300
Treatments
Esophageal atresia arm
Patient with esophageal atresia
control arm
Patient without esophageal atresia
Sponsors
Collaborators: Institut National de la Santé Et de la Recherche Médicale, France
Leads: University Hospital, Lille

This content was sourced from clinicaltrials.gov