Glucose Homeostasis, Metabolomics and Pregnancy Outcomes After Bariatric Surgery

Status: Recruiting
Location: See all (8) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The aim of the GLORIA study is to determine whether an altered glucose metabolism (with more hypoglycaemia and glycaemic variability) and altered metabolomics during pregnancy after bariatric surgery contribute to the increased risk for adverse pregnancy outcomes such as small-for-gestational age infants. In addition, the investigators also aim to evaluate whether continuous glucose monitoring (CGM) can be used to diagnose gestational diabetes (GDM).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:

• Age 18-45 years and with a singleton pregnancy with ultrasound-confirmed gestational age up to 11 weeks and 6 days

• for the group with bariatric surgery: history of gastric bypass (RYBG) or sleeve gastrectomy (SG)

• Participants need to speak and understand Flemish, French or English and have e-mail access.

Locations
Other Locations
Belgium
OLV-Aalst-Asse
RECRUITING
Aalst
UZA
RECRUITING
Antwerp
ZNA Antwerpen
RECRUITING
Antwerp
Imelda Bonheiden
RECRUITING
Bonheiden
AZ St-Jan Brugge
RECRUITING
Bruges
UZ Gent
RECRUITING
Ghent
AZ Groeninge Kortrijk
RECRUITING
Kortrijk
UZ Leuven
RECRUITING
Leuven
Contact Information
Primary
Katrien Benhalima, MD PhD
katrien.benhalima@uzleuven.be
+3216340614
Backup
Ellen Deleus, MD
ellen.deleus@uzleuven.be
Time Frame
Start Date: 2023-01-25
Estimated Completion Date: 2025-12
Participants
Target number of participants: 190
Treatments
pregnant group with bariatric surgery
pregnant women with a history of gastric bypass or sleeve gastrectomy
matched pregnant group without history of bariatric surgery
age-and BMI matched pregnant women without history of bariatric surgery
Related Therapeutic Areas
Sponsors
Collaborators: General Hospital Groeninge, Onze Lieve Vrouw Hospital, AZ Sint-Lucas Brugge, Imelda Hospital, Bonheiden, University Hospital, Antwerp, University Hospital, Ghent, Ziekenhuis Netwerk Antwerpen (ZNA)
Leads: Universitaire Ziekenhuizen KU Leuven

This content was sourced from clinicaltrials.gov