Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

The drainage angle in the anterior chamber of the eye mediates the outflow of aqueous humor, and pathological changes here can lead to high intraocular pressure and glaucoma. Minimally invasive glaucoma surgery, particularly angle surgery, has advanced recently, allowing clear visualization of angle structures like the trabecular meshwork and Schlemm's canal using surgical goniolens. Techniques for angle intervention include widening the angle, reopening closed angles, and rebuilding outflow pathways using methods such as laser peripheral iridotomy, Argon laser peripheral iridoplasty, and mechanical separation of adhered tissues. Our research team plans to conduct imaging studies to track the healing of angle tissues post-surgery, aiming to support innovation and standardization of minimally invasive angle surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 85
View:

• Glaucoma patients eligible for standalone or combined angle intervention surgeries, such as LPI, LPIP, goniosynechialysis, trabeculotomy alone or combined with surgical iridectomy or phacoemulsification and intraocular lens implantation;

• Patients capable of undergoing preoperative examinations including CASIA2-OCT (anterior segment OCT), UBM, slit-lamp gonioscopy, IOL Master (or other optical biometry);

• Patients willing to participate in this study, signing informed consent, and agreeing to follow-up according to the study protocol.

Locations
Other Locations
China
Zhongshan ophthalmic center
RECRUITING
Guangzhou
Contact Information
Primary
Xinbo Gao, MD
gaoxb@mail.sysu.edu.cn
+8618319579657
Time Frame
Start Date: 2023-12-01
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 300
Treatments
laser peripheral iridotomy/iridoplasty group
based on angle closure mechanism, procedures were chosen LPI alone or combined with ALPIp.~LPI: laser peripheral iridotomy; ALPIp: argon laser peripheral iridoplasty.
peripheral iridectomy based surgery combo
SPI combined with GSL or GSL+GT SPI: surgical peripheral iridectomy GSL:goniosynechialysis GT: goniotomy GSL and GT are both guided by surgical goniolens
phacoemulsification and intraocular lens implantation based surgery combo
PEI: phacoemulsification and intraocular lens implantation surgery combo includes GSL alone or GSL+GT.
ab interno goniotomy
GT was performed in the nasal-inferior quadrant or nasal quadrant because the collector channels were mainly concentrated in the nasal quadrant, by inserting the tip of a microblade (TMH; Tanito Microhook, Inami \& Co., Ltd., Tokyo, Japan) into Schlemm's canal, and then the inner wall of Schlemm's canal and trabecular meshwork was incised over 120°
Schlemm canaloplasty
performed in the nasal quadrant by the collector channels were mainly concentrated in the nasal quadrant, by inserting the tip of a microblade (TMH; Tanito Microhook, Inami \& Co., Ltd., Tokyo, Japan) into Schlemm's canal, and then the inner wall of Schlemm's canal and trabecular meshwork was incised over 120°
Sponsors
Leads: Zhongshan Ophthalmic Center, Sun Yat-sen University

This content was sourced from clinicaltrials.gov