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Optic Nerve Head Strain in Non-glaucoma Subjects

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 90
Healthy Volunteers: t
View:

• Adults who have no history of OAG

• Have an ocular examination by a glaucoma specialist with no indications of OAG

• Have normal optical coherence tomography findings in the retinal nerve fiber layer.

• Over age 30 will be included from

• Both sexes

• All ethnic groups.

• Optic neuropathy.

• Both suspects and those with glaucoma damage will be included.

• When both eyes meet inclusion and exclusion criteria, both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual.

Locations
United States
Maryland
Johns Hopkins Hospital
RECRUITING
Baltimore
Contact Information
Primary
Harry A Quigley, MD
hquigley@jhmi.edu
410 955 6051
Backup
Farzaneh Dadvar, MD
fdadvar1@jh.edu
Time Frame
Start Date: 2026-06-24
Estimated Completion Date: 2028-03-31
Participants
Target number of participants: 30
Treatments
Experimental: Study group
The participants will take an approved glaucoma eye drop, latanoprost, for less than one month, with pictures of the eyes at baseline and while taking the drop.
Related Therapeutic Areas
Sponsors
Collaborators: National Eye Institute (NEI)
Leads: Johns Hopkins University

This content was sourced from clinicaltrials.gov