A Trial to Evaluate the Safety and Preliminary Efficacy of Human Induced Pluripotent Stem Cell Derived Mesenchymal Stromal Cells in Subjects With Steroid-refractory Acute Graft-Versus-Host Disease
Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
A study to evaluate the safety and preliminary efficacy of iMSC in subjects with SR-aGVHD
Eligibility
Participation Requirements
Sex: All
Minimum Age: 4
Maximum Age: 70
Healthy Volunteers: f
View:
• Subjects who understand and voluntarily sign the Informed Consent Form(ICF); 2.4-70 years; 3.Subjects with SR-aGVHD; 4.ECOG≤2; 5.Subjects with II to IV grades of steroid hormone resistance;
Locations
Other Locations
China
Anhui Provincial Hospital
RECRUITING
Hefei
Contact Information
Primary
Xiaoyu Zhu, phd
xiaoyuz@ustc.edu.cn
+86 15255456091
Time Frame
Start Date: 2024-02-10
Estimated Completion Date: 2027-03-02
Participants
Target number of participants: 12
Treatments
Experimental: iMSC injection
Low dose injection once a week; Low dose injection twice a week; High dose injection once a week; High dose injection twice a week;
Related Therapeutic Areas
Sponsors
Leads: Anhui Provincial Hospital
Collaborators: Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences (IHCAMS)