• Age 18 years or above.

• Patients with pathologically confirmed HNSCC (except for nasopharyngeal carcinoma) and meet the following conditions:

‣ were newly diagnosed and without distant metastasis;

⁃ were deemed surgically resectable evaluated by a head and neck surgeon;

⁃ were willing to undergo surgery.

• Eastern Cooperative Oncology Group (ECOG) performance status 0-1.

• Adequate organ and bone marrow function:

‣ absolute neutrophil count ≥ 1.5 × 10\^9/L, hemoglobin ≥ 80 g/L, platelets ≥ 80 × 10\^9/L;

⁃ ALT, AST and ALP \< 2.5× upper limit of normal (ULN), total bilirubin ≤ 2×ULN;

⁃ albumin≥ 2.8 g/dL；

⁃ creatinine clearance ≥ 60 ml/min；

⁃ INR≤ 1.5；APTT≤ 1.5×ULN；

• Written informed consent.