Cerebral Hemodynamics and Cerebrospinal Fluid Dynamics in Postdural Puncture Headache An MRI Study for Exploring the Pathophysiological Mechanisms and Implication of Treatment
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 40
Healthy Volunteers: f
View:
• Postural puncture headache Age 20-40
Locations
Other Locations
Sweden
Umeå University Hospital
RECRUITING
Umeå
Contact Information
Primary
Erik Burman, MD
erik.burman@regionvasterbotten.se
907864594
Time Frame
Start Date: 2024-01-30
Estimated Completion Date: 2027-12-28
Participants
Target number of participants: 160
Treatments
Postdural puncture headache after lumbar puncture
Group of patients with aged 20-40 years undergoing planned neurological work-up including a lumbar puncture (LP). The group will include 40 subjects with and 40 subjects without PDPH.
Postdural puncture headache after accidental dural puncture
Group of parturients with EDA. The group will include 40 subjects with accidental dural puncture (ADP) with PDPH and 40 subjects without ADP and PDPH.
Related Therapeutic Areas
Sponsors
Leads: Umeå University
Collaborators: Region Västerbotten