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Visually Induced Dizziness in Concussed and Non-Concussed Dizzy Patients: Identifying the Pathophysiology of Postural Control Upon Optokinetic Stimuli

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This research project aims to measure how balance is affected by special visual stimulation. Dizziness caused by complex moving visual patterns, known as optokinetic stimulation, is usually called visually induced dizziness (VID). The study includes patients with persistent symptoms after a concussion and those with non-traumatic dizziness. Healthy participants serve as a control group for the comparison of balance and symptom responses. The optokinetic stimulation is done using either a physical rotating disk or a virtual reality (VR) headset. The visual effects are created by bright moving dots. During the stimulation, these patterns move in a specific manner and directions while the subject's balance is recorded. Symptoms such as dizziness, headache, and nausea are also documented. The goal of this project is to improve objective diagnosis of VID. By comparing patients and healthy subjects, the study aim to assess the severity of the disorder. It is also assumed that using different visual stimuli during the balance assessment will offer more sensitive and accurate results. In the long term, this innovative assessment method shall support clinicians to establish the diagnosis of VID, and improve the treatment and management of patients with VID.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:

• Age between 18 and 60 years

• Binocular vision

• Recent concussion/mTBI within 4 weeks to 18 months post-injury for concussed patients

• Diagnosis related to dizziness or VID within 4 weeks to 18 months for non-concussed dizzy patients (including vestibular migraine)

• Signed ICF for included participants or signed general consent for retrospectively included patients if an ICF cannot be obtained.

Locations
Other Locations
Switzerland
BrainCare Medical Group
RECRUITING
Zurich
University Hospital Zurich, Department of Neurology
RECRUITING
Zurich
Contact Information
Primary
Dominik Straumann, Prof. Dr. med.
Dominik.Straumann@uzh.ch
+41 44 255 55 64
Backup
Samuel Meyer, MSc
Samuel.Meyer3@uzh.ch
Time Frame
Start Date: 2025-05-14
Estimated Completion Date: 2027-10-31
Participants
Target number of participants: 240
Treatments
Active_comparator: Healthy Subjects (Physical / Virtual)
Cross-over design for healthy subjects, physical optokinetic stimulation in advance to virtual optokinetic stimulation.
Active_comparator: Healthy Subjects (Virtual / Physical)
Cross-over design for healthy subjects, virtual optokinetic stimulation in advance to physical optokinetic stimulation.
Experimental: Patients (Physical)
These patients are only examined with the physical stimulation to avoid excessive symptom burden.
Experimental: Patients (Virtual)
These patients are only examined with the virtual stimulation to avoid excessive symptom burden.
Related Therapeutic Areas
Sponsors
Leads: Dominik Straumann
Collaborators: BrainCare Medical Group, University Hospital, Zürich

This content was sourced from clinicaltrials.gov