Optimization of a Non-invasive Electrophysiological Method for Studying the Functionality of Auditory Nerve Fibers

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Acoustic overexposure can induced temporary or hearing loss. Usually hearing loss is associated with cochlear cell damages. Recently, a new pathological entity was described and called hidden hearing loss. In animal model, the histopathology revealed a selective reduction in the number of auditory fibers, resulting in a decrease in the amplitude of wave I of the auditory brainstem response. Electrocochleography (Ecog) is a method for recording the electrical potentials of the cochlea (e.g. wave I). In clinical routine, Ecog is performed invasively with sedation or local anesthesia. Actually, a non invasive approach could be perform but it seems necessary to optimize this method and to define reference values in healthy volunteers.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: t
View:

• Between 18 and 55 years old

• be affiliated to a social security system

• understand (oral and written) of the French language

• be a qualified hearing with normal tympanogram and audiogram

Locations
Other Locations
France
Chu Clermont Ferrand
RECRUITING
Clermont-ferrand
Contact Information
Primary
Lise Laclautre
promo_interne_drci@chu-clermontferrand.fr
334.73.754.963
Time Frame
Start Date: 2019-04-29
Estimated Completion Date: 2026-05
Participants
Target number of participants: 430
Treatments
Experimental: Cohort 1
Related Therapeutic Areas
Sponsors
Collaborators: Foundation of Gueules Cassées, Laboratory of Neurosensory Biophysics - UMR INSERM 1107., Region of Auvergne-Rhône-Alpes
Leads: University Hospital, Clermont-Ferrand

This content was sourced from clinicaltrials.gov