The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Age-related hearing loss, presbycusis, affects up to 50% of American adults. There are two main causes for presbycusis: 1) Progressive death of hair cells in the inner ear, and 2) Central hearing loss, or the reduced ability to decipher the sound source of interest from other competing sounds in a multi-source complex environment. The first cause is better understood and treatment options, such as hearing aids and cochlear implants, are available. However, central hearing loss is not as well understood and there is not a treatment available at this time. This study aims to advance our understanding of central hearing loss by evaluating the abilities of younger and older listeners in two primary outcome measures: to 1) neurologically process sound stimuli and 2) focus on conversational speech in the presence of spatially-separated competing background noise. A test using Auditory Brainstem Responses (ABR) will be used to evaluate the brain's response to clicking sounds. This study will assess all waveform data, but will focus particularly on wave III. Sentence in noise tests will be used to assess each subject's ability to process speech in noisy situations. Both the ABR and sentence in noise tests are non-invasive and are commonly used in audiology practices to diagnosis and treat a variety of audiological pathologies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 89
Healthy Volunteers: t
View:

• Subjects age ranges

• a. 21 years (inclusive) and 89years (inclusive)

• Subjects exhibiting no poorer than a mild hearing loss, defined as hearing thresholds no worse than 40dBHL at any test frequency 250-4000 Hz based on pure tone audiometry

• Subjects scoring 26 or higher on a screening measure of cognitive status (Montreal Cognitive Screening Assessment; MoCA)

Locations
United States
Colorado
University of Colorado School of Medicine
RECRUITING
Aurora
Contact Information
Primary
Shaylene Denham
shaylene.denham@cuanschutz.edu
303-724-8465
Time Frame
Start Date: 2020-10-01
Estimated Completion Date: 2026-05-29
Participants
Target number of participants: 200
Authors
Melinda Anderson
Related Therapeutic Areas
Sponsors
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH)
Leads: University of Colorado, Denver

This content was sourced from clinicaltrials.gov