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Clinical Utility of Residual Hearing in the Cochlear Implant Ear

Status: Recruiting
Location: See all (5) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The current study is a randomized multi-center clinical trial that investigates the role an intraoperative hearing monitoring system (electrocochleography) has on helping to save residual hearing in patients undergoing cochlear implantation (CI).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 79
Healthy Volunteers: f
View:

• Provision of signed and dated informed consent form.

• Adults, males and females, ages 18 -79 who have a bilateral sensorineural hearing loss with postlingual onset.

• Minimum of 30 days experience with appropriately fit binaural amplification (standardized National Acoustic Laboratories (NAL) fitting method) verified with real ear measurements within 5 dB SPL of targets.

• Limited benefit from conventional amplification in the best aided condition as defined by test scores of:

∙ The ear to implanted: Consonant-nucleus-consonant (CNC) words ≤ 60% or AzBio sentences (+10, +5 dB SNR ≤ 60% correct)

‣ Contralateral ear: ≤ 80% on CNC words or AzBio sentences (+10, +5 dB SNR ≤ 80% correct)

• Low frequency Pure Tone Average (PTA- 125, 250, 500 Hz) ≤ 55 dB HL in the ear to be implanted.

• Severe to profound mid to high-frequency sensorineural hearing loss (threshold average of 1000, 2000, 3000, and 4000 Hz ≥75 dB HL) in the ear to be implanted.

• Low frequency PTA ≤ 55 dB HL sloping to moderately severe to profound mid-to high frequency sensorineural hearing loss (threshold average of 1000, 2000, 3000, 4000 Hz ≥ 60 dB) in the contralateral ear.

• Proficient in English.

• Undergoing implantation with a current generation CI device from either Cochlear Limited or Advanced Bionics AG.

∙ Cochlear Limited devices include: Nucleus CI612, CI622, CI632, CI624

‣ Advanced Bionics AG devices include: HiFocus SlimJ, Mid-Scala

⁃ Stated willingness and ability to complete testing and all associated study visits.

Locations
United States
Minnesota
Mayo Clinic
RECRUITING
Rochester
Missouri
Washington University in St. Louis
RECRUITING
St Louis
North Carolina
University of North Carolina, Chapel Hill
RECRUITING
Chapel Hill
Ohio
Ohio State University Eye and Ear Institute
RECRUITING
Columbus
Wisconsin
Medical College of Wisconsin
RECRUITING
Milwaukee
Contact Information
Primary
Beth Miles-Markley
beth.miles-markley@osumc.edu
614-366-9244
Backup
Meghan Hiss, AuD
meghan.hiss@osumc.edu
Time Frame
Start Date: 2021-11-10
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 40
Treatments
Experimental: ECochG monitoring
For those randomized to the experimental group, the CI surgery will proceed in a standard fashion. However, the surgeon will utilize ECochG-guided monitoring by placing the external device coil and processor over the receiver/stimulator of the implanted components. Also, a sound applicator (i.e. speaker) will be placed in the external auditory canal by the surgeon. During electrode insertion the surgeon will utilize the ECochG feedback to adjust insertion if needed. That is, once the electrode has been inserted at least 75% (75% of the electrode contacts inside the cochlea), the surgeon may proceed to full insertion if indicated during ECochG feedback or may modify and/or cease electrode insertion if indicated by the ECochG feedback in attempts to preserve RH.
No_intervention: Control Group
For those randomized to the control group, they will receive their CI per the standard of care. That is, all procedures that take place during a routine CI surgery will be the same for those in the control group. As such, no ECochG monitoring will be performed. However, all study surgeons will be asked to adhere to soft surgical principles (non-traumatic cochlear opening, slow electrode insertions) to enhance HP outcomes even in the absence of intraoperative ECochG monitoring. Further, the standard of care for cochlear implantation is to perform full electrode insertions with all electrode contacts inside of the cochlea. Thus, for subjects in the control group, surgeons will be asked to perform full electrode insertions.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD)
Leads: Ohio State University

This content was sourced from clinicaltrials.gov